Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | cyclin B, putative | 0.0035 | 0.0134 | 0.0033 |
Trichomonas vaginalis | AGC family protein kinase | 0.0652 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0652 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0026 | 0 | 0.5 |
Echinococcus granulosus | cyclin B | 0.0059 | 0.0521 | 0.2232 |
Onchocerca volvulus | 0.0059 | 0.0521 | 0.5 | |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0059 | 0.0521 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0059 | 0.0521 | 0.0425 |
Trichomonas vaginalis | STE family protein kinase | 0.0652 | 1 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0059 | 0.0521 | 1 |
Schistosoma mansoni | cyclin B3 | 0.0143 | 0.1871 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0059 | 0.0521 | 0.0425 |
Trichomonas vaginalis | cyclin B, putative | 0.0059 | 0.0521 | 0.0425 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0143 | 0.1871 | 1 |
Trichomonas vaginalis | cyclin A, putative | 0.0059 | 0.0521 | 0.0425 |
Trichomonas vaginalis | cyclin B, putative | 0.0059 | 0.0521 | 0.0425 |
Trichomonas vaginalis | cyclin D, putative | 0.0035 | 0.0134 | 0.0033 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0143 | 0.1871 | 1 |
Trypanosoma brucei | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0652 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0652 | 1 | 1 |
Plasmodium vivax | serine/threonine protein kinase, putative | 0.0652 | 1 | 0.5 |
Trichomonas vaginalis | cyclin B3, putative | 0.0035 | 0.0134 | 0.0033 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0143 | 0.1871 | 1 |
Plasmodium falciparum | cyclin | 0.0035 | 0.0134 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0035 | 0.0134 | 0.0033 |
Trichomonas vaginalis | cyclins, putative | 0.0059 | 0.0521 | 0.0425 |
Schistosoma mansoni | cyclin B | 0.0059 | 0.0521 | 0.2232 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0649 | 0.9946 | 0.9943 |
Trichomonas vaginalis | cyclins, putative | 0.0059 | 0.0521 | 0.0425 |
Echinococcus multilocularis | cyclin B | 0.0059 | 0.0521 | 0.2232 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0143 | 0.1871 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0035 | 0.0134 | 0.0033 |
Trichomonas vaginalis | cyclins, putative | 0.0059 | 0.0521 | 0.0425 |
Trichomonas vaginalis | cyclin B, putative | 0.0059 | 0.0521 | 0.0425 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.0134 | 0.0033 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 23 % | Antiparasitic activity against Schistosoma mansoni infected in female Swiss-Webster mouse assessed as worm killing at 50 uM after 48 hrs by stereomicroscopy | ChEMBL. | 25016371 |
IC50 (binding) | > 50 uM | Inhibition of Schistosoma mansoni recombinant thioredoxin glutathione reductase assessed as 5-thio-2nitrobezoic acid formation after 3 mins | ChEMBL. | 25016371 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.