Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.8846 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.6717 | 0.7593 |
Onchocerca volvulus | 0.0375 | 1 | 1 | |
Entamoeba histolytica | aminopeptidase, putative | 0.011 | 0.2129 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2129 | 0.2129 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.011 | 0.2129 | 0.2129 |
Onchocerca volvulus | 0.011 | 0.2129 | 0.2129 | |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.011 | 0.2129 | 1 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0039 | 0 | 0.5 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.011 | 0.2129 | 0.2129 |
Toxoplasma gondii | aminopeptidase N protein | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0303 | 0.7871 | 0.8898 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0975 | 0.1102 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0072 | 0.0975 | 0.4578 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2129 | 0.2129 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0039 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.011 | 0.2129 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.011 | 0.2129 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0072 | 0.0975 | 0.0975 |
Echinococcus multilocularis | aminopeptidase N | 0.0375 | 1 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.011 | 0.2129 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.011 | 0.2129 | 0.2129 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0039 | 0 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.011 | 0.2129 | 0.2129 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0039 | 0 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.011 | 0.2129 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0975 | 0.1102 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.011 | 0.2129 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.0375 | 1 | 1 |
Schistosoma mansoni | family M1 non-peptidase homologue (M01 family) | 0.0072 | 0.0975 | 0.4578 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0039 | 0 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2129 | 0.2129 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.011 | 0.2129 | 1 |
Toxoplasma gondii | aminopeptidase n, putative | 0.0039 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.011 | 0.2129 | 1 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.011 | 0.2129 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2129 | 0.2129 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.011 | 0.2129 | 0.2129 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.011 | 0.2129 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.011 | 0.2129 | 0.2129 |
Brugia malayi | hypothetical protein | 0.011 | 0.2129 | 0.2129 |
Trypanosoma cruzi | aminopeptidase, putative | 0.011 | 0.2129 | 1 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.011 | 0.2129 | 1 |
Loa Loa (eye worm) | aminopeptidase N | 0.011 | 0.2129 | 0.2407 |
Brugia malayi | Peptidase family M1 containing protein | 0.011 | 0.2129 | 0.2129 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.011 | 0.2129 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.24 uM | Cytotoxicity against human NCI-H460 cells assessed as growth inhibition by MTT assay | ChEMBL. | 25091926 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 25091926 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.