Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | leucine-rich repeat kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Echinococcus granulosus | leucine rich repeat serine:threonine protein | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0003 | 0 | 0.5 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0465 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0465 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0465 | 1 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0465 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0465 | 1 | 1 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.007 | 0.1458 | 0.1458 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0003 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.007 | 0.1458 | 0.1458 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.0276 | 0.5919 | 0.5919 |
Leishmania major | hypothetical protein, conserved | 0.0003 | 0 | 0.5 |
Plasmodium vivax | ras-related protein Rab-5A, putative | 0.0003 | 0 | 0.5 |
Plasmodium falciparum | ras-related protein Rab-5A | 0.0003 | 0 | 0.5 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0465 | 1 | 1 |
Trypanosoma brucei | Rab-like 5, small G protein | 0.0003 | 0 | 0.5 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0465 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0003 | 0 | 0.5 |
Trypanosoma cruzi | Rab-like 5, small G protein | 0.0003 | 0 | 0.5 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.007 | 0.1458 | 0.1458 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0188 | 0.4016 | 0.4016 |
Trichomonas vaginalis | GTP binding protein rare7l, putative | 0.0003 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0003 | 0 | 0.5 |
Onchocerca volvulus | 0.0465 | 1 | 1 | |
Echinococcus granulosus | leucine rich repeat serine:threonine protein | 0.0071 | 0.1468 | 0.1468 |
Entamoeba histolytica | hypothetical protein | 0.0003 | 0 | 0.5 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0465 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0003 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0003 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 104 ml/min.kg | Clearance in human liver microsomes | ChEMBL. | 25113930 |
IC50 (binding) | = 496 nM | Inhibition of GST-tagged truncated LRRK2 (unknown origin) using fluorescein-labeled peptide LRRKtide as substrate by LANTHA screen assay in presence of 1 mM ATP | ChEMBL. | 25113930 |
IC50 (binding) | = 1310 nM | Inhibition of phosphorylation at S935 residue of wild-type full-length LRRK2 kinase (unknown origin) expressed in HEK 293 cells after 90 mins by ELISA | ChEMBL. | 25113930 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.