Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | amidase | 0.0084 | 0.649 | 0.649 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0005 | 0 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0058 | 0.4305 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.001 | 0.0405 | 0.0941 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0058 | 0.4305 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.001 | 0.0405 | 0.0405 |
Brugia malayi | Amidase family protein | 0.001 | 0.0405 | 0.0421 |
Plasmodium vivax | PST-A protein | 0.0058 | 0.4305 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0058 | 0.4305 | 1 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.001 | 0.0405 | 0.0941 |
Trypanosoma cruzi | mitogen-activated protein kinase kinase 5 | 0.0043 | 0.3144 | 0.7303 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.001 | 0.0405 | 0.5 |
Mycobacterium ulcerans | amidase | 0.001 | 0.0405 | 0.0941 |
Onchocerca volvulus | 0.0005 | 0 | 0.5 | |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0058 | 0.4305 | 1 |
Loa Loa (eye worm) | STE/STE7/MEK1 protein kinase | 0.0043 | 0.3144 | 0.316 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0127 | 1 | 1 |
Mycobacterium ulcerans | amidase | 0.001 | 0.0405 | 0.0941 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0058 | 0.4305 | 1 |
Trypanosoma brucei | mitogen-activated protein kinase kinase 5 | 0.0043 | 0.3144 | 0.7303 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0058 | 0.4305 | 1 |
Leishmania major | hypothetical protein, conserved | 0.001 | 0.0405 | 0.0941 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0058 | 0.4305 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0043 | 0.3144 | 0.7303 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.001 | 0.0405 | 0.0405 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.001 | 0.0405 | 0.0941 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.001 | 0.0405 | 0.0941 |
Schistosoma mansoni | protein kinase | 0.0043 | 0.3144 | 0.3144 |
Mycobacterium ulcerans | lysophospholipase | 0.0058 | 0.4305 | 1 |
Brugia malayi | Amidase family protein | 0.001 | 0.0405 | 0.0421 |
Brugia malayi | Dual specificity mitogen-activated protein kinase kinase mek-2 | 0.0043 | 0.3144 | 0.3263 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0084 | 0.649 | 0.649 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0058 | 0.4305 | 1 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.0072 | 0.5484 | 0.5512 |
Brugia malayi | putative amidase | 0.001 | 0.0405 | 0.0421 |
Mycobacterium ulcerans | amidase | 0.001 | 0.0405 | 0.0941 |
Trichomonas vaginalis | STE family protein kinase | 0.0043 | 0.3144 | 0.7303 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.001 | 0.0405 | 0.0941 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.001 | 0.0405 | 0.0941 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.649 | 0.6523 |
Plasmodium falciparum | esterase, putative | 0.0058 | 0.4305 | 1 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0005 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.001 | 0.0405 | 0.5 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.001 | 0.0405 | 0.0405 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.0043 | 0.3144 | 0.3144 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0058 | 0.4305 | 1 |
Brugia malayi | amidase | 0.0084 | 0.649 | 0.6735 |
Loa Loa (eye worm) | amidase | 0.001 | 0.0405 | 0.0407 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0058 | 0.4305 | 1 |
Mycobacterium ulcerans | amidase | 0.001 | 0.0405 | 0.0941 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0084 | 0.649 | 0.649 |
Plasmodium falciparum | lysophospholipase, putative | 0.0058 | 0.4305 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0058 | 0.4305 | 1 |
Trypanosoma cruzi | amidase, putative | 0.001 | 0.0405 | 0.0941 |
Leishmania major | mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 | 0.0043 | 0.3144 | 0.7303 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.001 | 0.0405 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0058 | 0.4305 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.001 | 0.0405 | 0.0405 |
Trypanosoma cruzi | amidase, putative | 0.001 | 0.0405 | 0.0941 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0058 | 0.4305 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.001 | 0.0405 | 0.0405 |
Mycobacterium ulcerans | amidase | 0.001 | 0.0405 | 0.0941 |
Trichomonas vaginalis | STE family protein kinase | 0.0043 | 0.3144 | 0.7303 |
Trypanosoma brucei | fatty-acid amide hydrolase, putative | 0.001 | 0.0405 | 0.0941 |
Loa Loa (eye worm) | raf kinase | 0.0126 | 0.9949 | 1 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0058 | 0.4305 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0058 | 0.4305 | 1 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.0043 | 0.3144 | 0.3144 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0084 | 0.649 | 0.649 |
Plasmodium falciparum | lysophospholipase, putative | 0.0058 | 0.4305 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0043 | 0.3144 | 0.5 |
Loa Loa (eye worm) | amidase | 0.001 | 0.0405 | 0.0407 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.001 | 0.0405 | 0.0941 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0058 | 0.4305 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0084 | 0.649 | 0.649 |
Leishmania major | monoglyceride lipase, putative | 0.0058 | 0.4305 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0058 | 0.4305 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.001 | 0.0405 | 0.0941 |
Brugia malayi | Raf kinase | 0.0122 | 0.9636 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0084 | 0.649 | 0.649 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.001 | 0.0405 | 0.0941 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0127 | 1 | 1 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.001 | 0.0405 | 0.0405 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 after 24 hrs by [3H]hypoxanthine incorporation assay | ChEMBL. | 25078311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.