Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | 0.0089 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0141 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0141 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0089 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0141 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0089 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0141 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0141 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 1 | 1 |
Onchocerca volvulus | 0.0089 | 0 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0141 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 44 uM | Displacement of [125I]glucagon from glucagon receptor in rat hepatocyte membranes after 30 mins by gamma-counting | ChEMBL. | 25127101 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.