Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0511 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0511 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0511 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0511 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0511 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0511 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0511 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0511 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0511 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0511 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 26 % | Inhibition of recombinant human TNFalpha binding to TNF receptor 1-ECD at 100 uM by surface plasmon resonance-based in vitro competitive binding assay | ChEMBL. | 25078315 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.