Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Stimulation of rat GLUT4-mediated glucose uptake in rat L6 cells expressing myc-tagged GLUT4 at 10 uM incubated for 16 hrs by scintillation counting based 2-[3H]DG uptake assay | ChEMBL. | 25129867 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.