Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0146 | 0.0168 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Plasmodium falciparum | kinesin-5 | 0.0163 | 0.1189 | 1 |
Brugia malayi | Kinesin motor domain containing protein | 0.0163 | 0.1189 | 1 |
Giardia lamblia | Kinesin-5 | 0.0163 | 0.1189 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0168 | 0.1229 | 0.1229 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0272 | 0.2291 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0146 | 0.123 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1229 | 0.1416 |
Echinococcus multilocularis | kinesin family 1 | 0.1255 | 1 | 1 |
Plasmodium vivax | kinesin-5 | 0.0163 | 0.1189 | 1 |
Echinococcus multilocularis | geminin | 0.0168 | 0.1229 | 0.1229 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1229 | 0.1416 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0146 | 0.123 |
Schistosoma mansoni | hypothetical protein | 0.1092 | 0.8684 | 1 |
Entamoeba histolytica | kinesin, putative | 0.0163 | 0.1189 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0272 | 0.2291 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0272 | 0.2291 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0163 | 0.1189 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0272 | 0.2291 |
Schistosoma mansoni | kinesin eg-5 | 0.0163 | 0.1189 | 0.1369 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0163 | 0.1189 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ke (functional) | = 16 nM | Antagonist activity at human kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-stimulated [35S]GTPgammaS binding | ChEMBL. | 25133923 |
Ke (functional) | = 724 nM | Antagonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS binding | ChEMBL. | 25133923 |
Ke (functional) | > 3 uM | Antagonist activity at human delta opioid receptor expressed in CHO cells assessed as inhibition of DPDPE-stimulated [35S]GTPgammaS binding | ChEMBL. | 25133923 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.