Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Homo sapiens | opiate receptor-like 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | opiate receptor-like 1 | 370 aa | 349 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | sex peptide receptor | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide s receptor | 0.0434 | 0 | 0.5 |
Brugia malayi | ORL1-like opioid receptor | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | allatostatin A receptor | 0.0434 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | dro:myosuppressin receptor | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | serotonin receptor | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide receptor | 0.0434 | 0 | 0.5 |
Onchocerca volvulus | 0.0434 | 0 | 0.5 | |
Onchocerca volvulus | 0.0434 | 0 | 0.5 | |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | fmrfamide receptor | 0.0434 | 0 | 0.5 |
Onchocerca volvulus | 0.0434 | 0 | 0.5 | |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0434 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0652 | 0.3972 | 0.3972 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0434 | 0 | 0.5 |
Onchocerca volvulus | 0.0434 | 0 | 0.5 | |
Brugia malayi | Serotonin receptor | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0434 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor | 0.0434 | 0 | 0.5 |
Onchocerca volvulus | 0.0434 | 0 | 0.5 | |
Brugia malayi | sulfakinin receptor protein | 0.0434 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0434 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0895 | 0.8408 | 0.8408 |
Onchocerca volvulus | 0.0434 | 0 | 0.5 | |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | orexin receptor type 2 | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0434 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1 | 0.0434 | 0 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0434 | 0 | 0.5 |
Onchocerca volvulus | 0.0434 | 0 | 0.5 | |
Onchocerca volvulus | 0.0434 | 0 | 0.5 | |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0434 | 0 | 0.5 |
Brugia malayi | Melatonin receptor type 1A | 0.0434 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0434 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0434 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0434 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0434 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0434 | 0 | 0.5 |
Brugia malayi | AKH receptor | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0434 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0434 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0434 | 0 | 0.5 |
Onchocerca volvulus | 0.0434 | 0 | 0.5 | |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0434 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0434 | 0 | 0.5 |
Onchocerca volvulus | 0.0434 | 0 | 0.5 | |
Onchocerca volvulus | 0.0434 | 0 | 0.5 | |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0434 | 0 | 0.5 |
Onchocerca volvulus | 0.0434 | 0 | 0.5 | |
Echinococcus granulosus | alpha 1A adrenergic receptor | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | g-protein coupled receptor | 0.0434 | 0 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | 7tm_1 domain containing protein | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | G protein coupled receptor 139 | 0.0434 | 0 | 0.5 |
Brugia malayi | Dopamine receptor | 0.0434 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0434 | 0 | 0.5 |
Brugia malayi | RE15519p | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0434 | 0 | 0.5 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0434 | 0 | 0.5 |
Onchocerca volvulus | 0.0434 | 0 | 0.5 | |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0434 | 0 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0959 | 0.9573 | 1 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0434 | 0 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0434 | 0 | 0.5 |
Onchocerca volvulus | 0.0434 | 0 | 0.5 | |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0434 | 0 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0434 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0434 | 0 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0434 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0434 | 0 | 0.5 |
Onchocerca volvulus | 0.0434 | 0 | 0.5 | |
Echinococcus granulosus | neuropeptide receptor | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0434 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0434 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0434 | 0 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0628 | 0.3546 | 1 |
Brugia malayi | putative neuropeptide receptor | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | 7TM GPCR rhodopsin | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | peptide allatostatin:somatostatin | 0.0434 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0434 | 0 | 0.5 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.0434 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0434 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0434 | 0 | 0.5 |
Onchocerca volvulus | 0.0434 | 0 | 0.5 | |
Onchocerca volvulus | 0.0434 | 0 | 0.5 | |
Echinococcus granulosus | somatostatin receptor | 0.0434 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.36 nM | Displacement of [3H]naloxone from human MOP receptor expressed in CHO-K1 cells by scintillation proximity assay | ChEMBL. | 25147603 |
Ki (binding) | = 1.1 nM | Displacement of [3H]nociceptin from human NOP receptor expressed in CHO-K1 cells by scintillation proximity assay | ChEMBL. | 25147603 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.