Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | hydroxysteroid 11-beta dehydrogenase 1 | Starlite/ChEMBL | References |
Homo sapiens | hydroxysteroid (11-beta) dehydrogenase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable oxidoreductase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Mycobacterium ulcerans | short chain dehydrogenase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxysteroid 11-beta dehydrogenase 1 | 292 aa | 246 aa | 25.2 % |
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxysteroid (11-beta) dehydrogenase 1 | 292 aa | 250 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 0.6041 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0497 | 0.6927 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.4407 | 0.7295 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0146 | 0.0886 | 0.5 |
Onchocerca volvulus | 0.0497 | 0.6927 | 1 | |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0146 | 0.0886 | 0.5 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0146 | 0.0886 | 0.1279 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0146 | 0.0886 | 0.1279 |
Loa Loa (eye worm) | aminopeptidase N | 0.0146 | 0.0886 | 0.1467 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0146 | 0.0886 | 0.1279 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0146 | 0.0886 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0146 | 0.0886 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0146 | 0.0886 | 1 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0403 | 0.5293 | 0.8762 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0146 | 0.0886 | 0.5 |
Brugia malayi | Peptidase family M1 containing protein | 0.0497 | 0.6927 | 1 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0146 | 0.0886 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0146 | 0.0886 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0146 | 0.0886 | 0.1279 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0146 | 0.0886 | 0.1279 |
Entamoeba histolytica | aminopeptidase, putative | 0.0146 | 0.0886 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0146 | 0.0886 | 0.1279 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0676 | 1 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0146 | 0.0886 | 1 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0146 | 0.0886 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0146 | 0.0886 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0497 | 0.6927 | 1 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0146 | 0.0886 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.24 uM | Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol by scintillation proximity assay | ChEMBL. | 25098388 |
IC50 (binding) | = 10 uM | Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol by scintillation proximity assay | ChEMBL. | 25098388 |
Inhibition (binding) | > 60 % | Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol at 10 uM by scintillation proximity assay | ChEMBL. | 25098388 |
Inhibition (binding) | > 60 % | Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol at 10 uM by scintillation proximity assay | ChEMBL. | 25098388 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.