Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.06418 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.06418 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0672 | 0.5 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.06418 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.06418 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0672 | 0.5 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0672 | 0.5 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.06418 | 0.5 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0672 | 0.5 | 0.5 |
Echinococcus multilocularis | laminin | 0.0672 | 0.5 | 0.5 |
Echinococcus multilocularis | Tolloid protein 1 | 0.06418 | 0.5 | 0.5 |
Brugia malayi | Fibulin-1 precursor | 0.06418 | 0.5 | 0.5 |
Echinococcus granulosus | laminin | 0.06418 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0672 | 0.5 | 0.5 |
Schistosoma mansoni | egf-like domain protein | 0.0672 | 0.5 | 0.5 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.06418 | 0.5 | 0.5 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0672 | 0.5 | 0.5 |
Brugia malayi | Fibulin-1 precursor | 0.0672 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0672 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.06418 | 0.5 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.06418 | 0.5 | 0.5 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.06418 | 0.5 | 0.5 |
Echinococcus multilocularis | fibrillin 1 | 0.06418 | 0.5 | 0.5 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0672 | 0.5 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0672 | 0.5 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.06418 | 0.5 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.06418 | 0.5 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.06418 | 0.5 | 0.5 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0672 | 0.5 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.0672 | 0.5 | 0.5 |
Schistosoma mansoni | egf-like domain protein | 0.06418 | 0.5 | 0.5 |
Echinococcus granulosus | laminin | 0.0672 | 0.5 | 0.5 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.06418 | 0.5 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0672 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0672 | 0.5 | 0.5 |
Echinococcus multilocularis | fibrillin 1 | 0.0672 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0672 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.06418 | 0.5 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.0672 | 0.5 | 0.5 |
Echinococcus multilocularis | laminin | 0.06418 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.06418 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1 ug ml-1 | Antimicrobial activity against Mycobacterium tuberculosis H37Ra after 5 days by serial macrobroth dilution method | ChEMBL. | 25150092 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mycobacterium tuberculosis | 25150092 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.