Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.2452 | 0.2887 |
Brugia malayi | Muscleblind-like protein | 0.0087 | 0.0651 | 0.0767 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0138 | 0.1883 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 0.8493 | 1 |
Loa Loa (eye worm) | trypsin family protein | 0.0149 | 0.2163 | 0.2546 |
Onchocerca volvulus | 0.0411 | 0.8493 | 1 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0149 | 0.2163 | 0.2546 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.2163 | 0.2546 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2163 | 0.2546 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0149 | 0.2163 | 0.2546 |
Brugia malayi | Carboxylesterase family protein | 0.0161 | 0.2452 | 0.2887 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2163 | 0.2546 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0411 | 0.8493 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0651 | 0.0767 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0149 | 0.2163 | 0.2546 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0149 | 0.2163 | 0.2546 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0411 | 0.8493 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0197 | 0.3316 | 0.3316 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0149 | 0.2163 | 0.2546 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0149 | 0.2163 | 0.2163 |
Brugia malayi | Trypsin family protein | 0.0149 | 0.2163 | 0.2546 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0149 | 0.2163 | 0.2546 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0087 | 0.0651 | 0.0651 |
Brugia malayi | hypothetical protein | 0.0149 | 0.2163 | 0.2546 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0149 | 0.2163 | 0.2163 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0138 | 0.1883 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2163 | 0.2546 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0149 | 0.2163 | 0.2546 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0149 | 0.2163 | 0.2546 |
Echinococcus multilocularis | muscleblind protein | 0.0087 | 0.0651 | 0.0651 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0149 | 0.2163 | 0.2546 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.2163 | 0.2546 |
Echinococcus granulosus | tumor protein p63 | 0.0197 | 0.3316 | 0.3904 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0149 | 0.2163 | 0.2546 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0149 | 0.2163 | 0.2546 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0149 | 0.2163 | 0.2546 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0149 | 0.2163 | 0.2546 |
Brugia malayi | Trypsin family protein | 0.0149 | 0.2163 | 0.2546 |
Mycobacterium ulcerans | hypothetical protein | 0.0149 | 0.2163 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0149 | 0.2163 | 0.2546 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0161 | 0.2452 | 0.2452 |
Brugia malayi | Carboxylesterase family protein | 0.0161 | 0.2452 | 0.2887 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0411 | 0.8493 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0161 | 0.2452 | 0.2887 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0149 | 0.2163 | 0.2546 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0149 | 0.2163 | 0.2546 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2163 | 0.2546 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0138 | 0.1883 | 0.2217 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.2452 | 0.2887 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0411 | 0.8493 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0138 | 0.1883 | 0.8707 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0149 | 0.2163 | 0.2546 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2163 | 0.2546 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0149 | 0.2163 | 0.2546 |
Brugia malayi | Protein kinase domain containing protein | 0.0411 | 0.8493 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0138 | 0.1883 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0161 | 0.2452 | 0.2452 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0149 | 0.2163 | 0.2546 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0411 | 0.8493 | 1 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0149 | 0.2163 | 0.2163 |
Echinococcus granulosus | Mastin | 0.0149 | 0.2163 | 0.2546 |
Brugia malayi | Trypsin family protein | 0.0149 | 0.2163 | 0.2546 |
Echinococcus multilocularis | Mastin | 0.0149 | 0.2163 | 0.2163 |
Brugia malayi | Kringle domain containing protein | 0.0411 | 0.8493 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2163 | 0.2546 |
Echinococcus multilocularis | enteropeptidase | 0.0149 | 0.2163 | 0.2163 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0149 | 0.2163 | 0.2546 |
Echinococcus granulosus | carboxylesterase 5A | 0.0161 | 0.2452 | 0.2887 |
Toxoplasma gondii | kringle domain-containing protein | 0.0411 | 0.8493 | 1 |
Echinococcus granulosus | enteropeptidase | 0.0149 | 0.2163 | 0.2546 |
Brugia malayi | Trypsin family protein | 0.0149 | 0.2163 | 0.2546 |
Echinococcus granulosus | muscleblind protein | 0.0087 | 0.0651 | 0.0767 |
Echinococcus granulosus | acetylcholinesterase | 0.0161 | 0.2452 | 0.2887 |
Echinococcus granulosus | acetylcholinesterase | 0.0161 | 0.2452 | 0.2887 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0149 | 0.2163 | 0.2546 |
Echinococcus multilocularis | acetylcholinesterase | 0.0161 | 0.2452 | 0.2452 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0161 | 0.2452 | 0.2887 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0138 | 0.1883 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0149 | 0.2163 | 0.2546 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0149 | 0.2163 | 0.2546 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0138 | 0.1883 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2163 | 0.2546 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0149 | 0.2163 | 0.2163 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0651 | 0.0767 |
Schistosoma mansoni | hypothetical protein | 0.0411 | 0.8493 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0149 | 0.2163 | 0.2546 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0149 | 0.2163 | 0.2546 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0161 | 0.2452 | 0.2887 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0411 | 0.8493 | 0.8493 |
Leishmania major | hypothetical protein, conserved | 0.0411 | 0.8493 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.