Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | References | |
Homo sapiens | endothelial PAS domain protein 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypoxia-induced factor 1 | Get druggable targets OG5_131074 | All targets in OG5_131074 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_131074 | All targets in OG5_131074 |
Brugia malayi | hypoxia-induced factor 1 | Get druggable targets OG5_131074 | All targets in OG5_131074 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131074 | All targets in OG5_131074 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0158 | 0.0295 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0158 | 0.0295 | 0.0295 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0158 | 0.0295 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0158 | 0.0295 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0158 | 0.0295 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0158 | 0.0295 | 0.0295 |
Echinococcus granulosus | FTZ F1 alpha | 0.0158 | 0.0295 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0158 | 0.0295 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0158 | 0.0295 | 0.0295 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0158 | 0.0295 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0364 | 0.1784 | 0.1535 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0158 | 0.0295 | 0.0295 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0158 | 0.0295 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0158 | 0.0295 | 0.5 |
Brugia malayi | hypothetical protein | 0.0394 | 0.2006 | 0.2006 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0158 | 0.0295 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0158 | 0.0295 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1497 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0158 | 0.0295 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0158 | 0.0295 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.2006 | 0.1763 |
Brugia malayi | nuclear hormone receptor | 0.0158 | 0.0295 | 0.0295 |
Schistosoma mansoni | thyroid hormone receptor | 0.0158 | 0.0295 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0158 | 0.0295 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0158 | 0.0295 | 0.0295 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0158 | 0.0295 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0158 | 0.0295 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0158 | 0.0295 | 0.0295 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0158 | 0.0295 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0158 | 0.0295 | 0.0295 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0158 | 0.0295 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0158 | 0.0295 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0158 | 0.0295 | 0.0295 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0158 | 0.0295 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0158 | 0.0295 | 0.0295 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0158 | 0.0295 | 0.0295 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0158 | 0.0295 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0158 | 0.0295 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0158 | 0.0295 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0158 | 0.0295 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0158 | 0.0295 | 0.0295 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0158 | 0.0295 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0158 | 0.0295 | 0.0295 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0158 | 0.0295 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.1497 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0158 | 0.0295 | 0.0295 |
Brugia malayi | hypoxia-induced factor 1 | 0.0364 | 0.1784 | 0.1784 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0158 | 0.0295 | 0.0295 |
Brugia malayi | nuclear receptor NHR-88 | 0.0158 | 0.0295 | 0.0295 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0158 | 0.0295 | 0.0295 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0158 | 0.0295 | 0.0295 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0158 | 0.0295 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0158 | 0.0295 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0158 | 0.0295 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0158 | 0.0295 | 1 |
Brugia malayi | steroid hormone receptor | 0.0158 | 0.0295 | 0.0295 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.021 uM | Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay | ChEMBL. | 25139751 |
Survival (ADMET) | = 50 day | Toxicity in BALB/cA mouse xenografted with human U251 cells assessed as mouse survival at 50 mg/kg/day, po | ChEMBL. | 25139751 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.