Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | leucine-rich repeat kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | leucine rich repeat serine:threonine protein | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0393 | 0.3333 | 0.5018 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0323 | 0.2732 | 0.4113 |
Trypanosoma cruzi | Rab-like 5, small G protein | 0.0003 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0003 | 0 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0716 | 0.609 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0003 | 0 | 0.5 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.007 | 0.0575 | 0.0866 |
Loa Loa (eye worm) | matrixin family protein | 0.0716 | 0.609 | 0.917 |
Loa Loa (eye worm) | matrixin family protein | 0.078 | 0.6642 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1173 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0003 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0457 | 0.3884 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0323 | 0.2732 | 0.4113 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0393 | 0.3333 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | GTP binding protein rare7l, putative | 0.0003 | 0 | 0.5 |
Trypanosoma brucei | Rab-like 5, small G protein | 0.0003 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0393 | 0.3333 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0457 | 0.3884 | 0.5848 |
Brugia malayi | Matrixin family protein | 0.0323 | 0.2732 | 0.4113 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0003 | 0 | 0.5 |
Plasmodium falciparum | ras-related protein Rab-5A | 0.0003 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0003 | 0 | 0.5 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.007 | 0.0575 | 0.0575 |
Loa Loa (eye worm) | hypothetical protein | 0.0323 | 0.2732 | 0.4113 |
Onchocerca volvulus | Matrilysin homolog | 0.0323 | 0.2732 | 0.4486 |
Onchocerca volvulus | 0.0323 | 0.2732 | 0.4486 | |
Brugia malayi | Protein kinase domain containing protein | 0.007 | 0.0575 | 0.0866 |
Brugia malayi | Matrixin family protein | 0.0323 | 0.2732 | 0.4113 |
Brugia malayi | Matrixin family protein | 0.0323 | 0.2732 | 0.4113 |
Echinococcus granulosus | leucine rich repeat serine:threonine protein | 0.0071 | 0.0579 | 0.0579 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0003 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0003 | 0 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0716 | 0.609 | 1 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0323 | 0.2732 | 0.7033 |
Brugia malayi | Matrixin family protein | 0.078 | 0.6642 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0393 | 0.3333 | 0.5018 |
Brugia malayi | Matrixin family protein | 0.0323 | 0.2732 | 0.4113 |
Plasmodium vivax | ras-related protein Rab-5A, putative | 0.0003 | 0 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0393 | 0.3333 | 0.5 |
Onchocerca volvulus | 0.0457 | 0.3884 | 0.6378 | |
Loa Loa (eye worm) | hypothetical protein | 0.0323 | 0.2732 | 0.4113 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.204 uM | Inhibition of recombinant LRRK2 (unknown origin) using gamma-32P-ATP assessed as LRRKtide substrate phosphorylation level by autoradiography | ChEMBL. | 25219901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.