Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | leucine-rich repeat kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | leucine rich repeat serine:threonine protein | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | Get druggable targets OG5_131478 | All targets in OG5_131478 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0023 | 0.0909 | 0.3578 |
Loa Loa (eye worm) | TKL/LRRK protein kinase | 0.007 | 0.5024 | 0.5024 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0042 | 0.2539 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.01 | 0.7624 | 0.8585 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.01 | 0.7624 | 0.8585 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0127 | 1 | 1 |
Echinococcus multilocularis | leucine rich repeat serine:threonine protein | 0.007 | 0.5024 | 0.5024 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1256 | 0.1256 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0023 | 0.0909 | 0.1849 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0114 | 0.8881 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.6341 | 0.6341 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.6341 | 0.6341 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0127 | 1 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0023 | 0.0909 | 0.3578 |
Leishmania major | DNA topoisomerase ii | 0.0114 | 0.8881 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.3796 | 0.3796 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0023 | 0.0909 | 0.3578 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0042 | 0.2539 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0122 | 0.9509 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.3796 | 0.3796 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0127 | 1 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0127 | 1 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0127 | 1 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0127 | 1 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0042 | 0.2539 | 0.2539 |
Brugia malayi | Protein kinase domain containing protein | 0.007 | 0.5024 | 0.5024 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0114 | 0.8881 | 1 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0023 | 0.0909 | 0.0909 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0114 | 0.8881 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0127 | 1 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0114 | 0.8881 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0023 | 0.0909 | 0.0909 |
Trypanosoma brucei | DNA topoisomerase ii | 0.01 | 0.7624 | 0.8585 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0042 | 0.2539 | 1 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0023 | 0.0909 | 0.1849 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0127 | 1 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0092 | 0.6943 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0127 | 1 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0023 | 0.0909 | 0.0909 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0042 | 0.2539 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1256 | 0.1256 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1256 | 0.1256 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.01 | 0.7624 | 0.8585 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0092 | 0.6943 | 1 |
Echinococcus granulosus | leucine rich repeat serine:threonine protein | 0.0071 | 0.5065 | 0.5065 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0042 | 0.2539 | 0.5167 |
Brugia malayi | Probable DNA topoisomerase II | 0.0127 | 1 | 1 |
Mycobacterium leprae | Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( | 0.0013 | 0 | 0.5 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0042 | 0.2539 | 0.2539 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0092 | 0.6943 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0069 | 0.4915 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0042 | 0.2539 | 0.2539 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0127 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.046 uM | Inhibition of recombinant LRRK2 (unknown origin) using gamma-32P-ATP assessed as LRRKtide substrate phosphorylation level by autoradiography | ChEMBL. | 25219901 |
IC50 (binding) | = 0.064 uM | Inhibition of recombinant LRRK2 G2019S mutant (unknown origin) using gamma-32P-ATP assessed as LRRKtide substrate phosphorylation level by autoradiography | ChEMBL. | 25219901 |
Inhibition (binding) | = 19 % | Inhibition of human recombinant GSK3beta using CFFKNIVTPRTPPPSQGK-amide substrate after 90 mins incubation by LANCE method | ChEMBL. | 25219901 |
Inhibition (binding) | = 30 % | Inhibition of human recombinant GSK3alpha using CFFKNIVTPRTPPPSQGK-amide substrate after 60 mins incubation by LANCE method | ChEMBL. | 25219901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.