Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0309 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0053 | 0.1554 | 0.0358 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0309 | 1 | 1 |
Onchocerca volvulus | 0.0006 | 0.0007 | 1 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0006 | 0.0007 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0006 | 0.0007 | 1 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0006 | 0.0007 | 1 |
Echinococcus granulosus | myosin light chain kinase smooth muscle | 0.0216 | 0.6945 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase | 0.0216 | 0.6945 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0146 | 0.4631 | 0.3871 |
Loa Loa (eye worm) | CAMK protein kinase | 0.0006 | 0.0007 | 1 |
Brugia malayi | protein unc-22 | 0.0006 | 0.0007 | 1 |
Echinococcus granulosus | titin | 0.0006 | 0.0007 | 0.001 |
Toxoplasma gondii | hypothetical protein | 0.005 | 0.1451 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0146 | 0.4631 | 0.3871 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0006 | 0.0007 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0163 | 0.5176 | 0.5 |
Echinococcus granulosus | titin | 0.0006 | 0.0007 | 0.001 |
Echinococcus multilocularis | titin | 0.0006 | 0.0007 | 0.001 |
Mycobacterium ulcerans | hypothetical protein | 0.0163 | 0.5176 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0309 | 1 | 1 |
Schistosoma mansoni | titin | 0.0006 | 0.0007 | 1 |
Echinococcus multilocularis | myosin light chain kinase, smooth muscle | 0.0216 | 0.6945 | 1 |
Echinococcus granulosus | serine:threonine protein kinase | 0.0216 | 0.6945 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 105.2 % | Cytotoxicity against mouse RAW264.7 cells assessed as survival rate at 10 uM after 24 hrs by MTT assay | ChEMBL. | 25200306 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.