Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | sterol 24-c-methyltransferase, putative | 0.0563 | 1 | 0.5 |
Trypanosoma cruzi | sterol 24-c-methyltransferase, putative | 0.0563 | 1 | 0.5 |
Brugia malayi | S-adenosyl-methionine cycloartenol-C24-methyltransferase | 0.0274 | 0.4299 | 1 |
Trypanosoma brucei | sterol 24-c-methyltransferase, putative | 0.0563 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0101 | 0.0236 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0101 | 0.0236 |
Echinococcus multilocularis | geminin | 0.0165 | 0.2147 | 1 |
Echinococcus granulosus | geminin | 0.0165 | 0.2147 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.0101 | 0.0236 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.4299 | 1 |
Brugia malayi | RNA binding protein | 0.0062 | 0.0101 | 0.0236 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.2147 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.0101 | 0.0236 |
Leishmania major | sterol 24-c-methyltransferase, putative | 0.0563 | 1 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0101 | 0.0236 |
Trypanosoma cruzi | sterol 24-c-methyltransferase, putative | 0.0563 | 1 | 0.5 |
Trypanosoma brucei | sterol 24-c-methyltransferase, putative | 0.0563 | 1 | 1 |
Trypanosoma brucei | Sterol methyltransferase, putative | 0.0563 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.2147 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of human recombinant Sphk1 at 10 uM after 30 mins by ADP2 fluorescence intensity assay | ChEMBL. | 25150091 | |
Inhibition (binding) | Inhibition of human recombinant Sphk2 at 10 uM after 60 mins by ADP2 fluorescence intensity assay | ChEMBL. | 25150091 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.