Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 184 uM | Antiparasitic activity against Toxoplasma gondii infected in human foreskin fibroblasts assessed as tachyzoite growth inhibition after 5 days by colorimetric assay | ChEMBL. | 25140751 |
TD50 (ADMET) | >= 320 uM | Cytotoxicity against human foreskin fibroblasts after 5 days by colorimetric assay | ChEMBL. | 25140751 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.