Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.2837 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2032 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.2837 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2032 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.1145 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.2032 | 0.7164 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.2032 | 0.7164 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.1145 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.2032 | 0.7164 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0064 | 0.4316 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.2837 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2837 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.2837 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.2837 | 1 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0133 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.1145 | 0.5 |
Trypanosoma brucei | beta lactamase | 0.0064 | 0.4316 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.2032 | 0.7164 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.1145 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.1145 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2837 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2032 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2837 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.1145 | 0.3031 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.1145 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.2837 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.1145 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2032 | 0.5 |
Brugia malayi | hypothetical protein | 0.0036 | 0.2032 | 0.6687 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 52 uM | Antiparasitic activity against Toxoplasma gondii infected in human foreskin fibroblasts assessed as tachyzoite growth inhibition after 5 days by colorimetric assay | ChEMBL. | 25140751 |
TD50 (ADMET) | = 102 uM | Cytotoxicity against human foreskin fibroblasts after 5 days by colorimetric assay | ChEMBL. | 25140751 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.