Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.0037 | 1 | 0.5 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.0037 | 1 | 0.5 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Giardia lamblia | Macrophage migration inhibitory factor | 0.0037 | 1 | 0.5 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0037 | 1 | 0.5 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0037 | 1 | 0.5 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.0037 | 1 | 0.5 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.0037 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 1 | 0.5 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0037 | 1 | 1 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.0037 | 1 | 0.5 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.0037 | 1 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0037 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 30000 nM | Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin challenge measured after 30 mins by TR-FRET assay | ChEMBL. | 25241924 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.