Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.041 | 0.8974 | 0.8776 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.6116 | 0.5364 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0112 | 0.1325 | 0.8166 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.014 | 0.2056 | 0.352 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.044 | 0.9725 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0123 | 0.1622 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0152 | 0.2354 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0103 | 0.1109 | 0.1898 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.2354 | 0.0873 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0288 | 0.5841 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0152 | 0.2354 | 0.1445 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 739 after 24 hrs by well diffusion method | ChEMBL. | 25241926 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.