Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | signal transducer and activator of transcription 3 (acute-phase response factor) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | glucose transporter, lmgt3 | 0.0032 | 0 | 0.5 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0103 | 0.4456 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0 | 0.5 |
Leishmania major | glucose transporter, lmgt2 | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0103 | 0.4456 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0103 | 0.4456 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0103 | 0.4456 | 0.5 |
Plasmodium falciparum | hexose transporter | 0.0103 | 0.4456 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0103 | 0.4456 | 1 |
Leishmania major | glucose transporter, lmgt1 | 0.0032 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0103 | 0.4456 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0103 | 0.4456 | 0.5 |
Trypanosoma brucei | glucose transporter 1E | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.4456 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0103 | 0.4456 | 1 |
Plasmodium vivax | hexose transporter | 0.0103 | 0.4456 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0103 | 0.4456 | 1 |
Trypanosoma cruzi | hexose transporter | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0103 | 0.4456 | 1 |
Trypanosoma brucei | glucose transporter 2A | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0103 | 0.4456 | 1 |
Loa Loa (eye worm) | STAT protein | 0.0191 | 1 | 1 |
Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0032 | 0 | 0.5 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0103 | 0.4456 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0103 | 0.4456 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.0032 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11.2 uM | Inhibition of IL-6-induced STAT3 phosphorylation in human Cal33 cells assessed as nuclear translocation by Western blot analysis | ChEMBL. | 25288188 |
IC50 (binding) | > 50 uM | Inhibition of IFNgamma-induced STAT1 phosphorylation in human Cal33 cells by Western blot analysis | ChEMBL. | 25288188 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.