Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | G protein-coupled receptor 119 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | G protein-coupled receptor 119 | 335 aa | 274 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0284 | 0.208 | 0.5 |
Leishmania major | monoglyceride lipase, putative | 0.0284 | 0.208 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0284 | 0.208 | 1 |
Brugia malayi | amidase | 0.0303 | 0.2235 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0284 | 0.208 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0284 | 0.208 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0037 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0284 | 0.208 | 0.5 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0037 | 0 | 0.5 |
Plasmodium falciparum | esterase, putative | 0.0284 | 0.208 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0284 | 0.208 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0284 | 0.208 | 0.5 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0299 | 0.2207 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0284 | 0.208 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0284 | 0.208 | 0.5 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0299 | 0.2207 | 0.2207 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0284 | 0.208 | 1 |
Schistosoma mansoni | amidase | 0.0303 | 0.2235 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0284 | 0.208 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0284 | 0.208 | 0.5 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0284 | 0.208 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0303 | 0.2235 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0284 | 0.208 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0037 | 0 | 0.5 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0284 | 0.208 | 0.5 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.1228 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0303 | 0.2235 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0303 | 0.2235 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0303 | 0.2235 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0303 | 0.2235 | 1 |
Plasmodium vivax | PST-A protein | 0.0284 | 0.208 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0284 | 0.208 | 0.208 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0284 | 0.208 | 0.5 |
Mycobacterium ulcerans | lysophospholipase | 0.0284 | 0.208 | 0.208 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0303 | 0.2235 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 10000 nM | Agonist activity at human GPR119 | ChEMBL. | 25208139 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.