Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0095 | 0.032 | 0.2695 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0051 | 0.0114 | 0.0959 |
Brugia malayi | Kinesin motor domain containing protein | 0.0281 | 0.1189 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0041 | 0.0068 | 0.0569 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0088 | 0.0287 | 0.0227 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.013 | 0.0481 | 0.0423 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0481 | 0.4044 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0057 | 0.0141 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0057 | 0.0141 | 0.0093 |
Plasmodium falciparum | kinesin-5 | 0.0281 | 0.1189 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0105 | 0.0367 | 0.3085 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0061 | 0.0512 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0051 | 0.0114 | 0.0062 |
Loa Loa (eye worm) | glutamate receptor | 0.0105 | 0.0367 | 0.3085 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.013 | 0.0481 | 0.0423 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.012 | 0.0434 | 0.0433 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0281 | 0.1189 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0281 | 0.1189 | 0.5 |
Schistosoma mansoni | kinesin eg-5 | 0.0281 | 0.1189 | 0.1308 |
Plasmodium vivax | kinesin-5 | 0.0281 | 0.1189 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.188 | 0.8684 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0141 | 0.1189 |
Echinococcus granulosus | caspase 2 | 0.0057 | 0.0141 | 0.0081 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0088 | 0.0287 | 0.0262 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0787 | 0.3561 | 0.3521 |
Brugia malayi | Cell death protein 3 precursor | 0.0057 | 0.0141 | 0.1189 |
Brugia malayi | hypothetical protein | 0.004 | 0.0061 | 0.0512 |
Echinococcus multilocularis | kinesin family 1 | 0.2161 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0088 | 0.0287 | 0.0227 |
Echinococcus multilocularis | caspase 2 | 0.0057 | 0.0141 | 0.0081 |
Entamoeba histolytica | kinesin, putative | 0.0281 | 0.1189 | 0.5 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0281 | 0.1189 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 46.17 ug ml-1 | Anticancer activity against human HeLa cells after 24 hrs by MTT assay | ChEMBL. | 25305717 |
IC50 (functional) | > 100 ug ml-1 | Anticancer activity against human MCF7 cells after 24 hrs by MTT assay | ChEMBL. | 25305717 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.