Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase | Starlite/ChEMBL | References |
Homo sapiens | baculoviral IAP repeat containing 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0114 | 0 | 0.5 | |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0752 | 0.1698 | 1 |
Schistosoma mansoni | amidase | 0.0752 | 0.1698 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0653 | 0.1435 | 0.5 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0752 | 0.1698 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0752 | 0.1698 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0653 | 0.1435 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0653 | 0.1435 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0653 | 0.1435 | 0.5 |
Brugia malayi | amidase | 0.0752 | 0.1698 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0653 | 0.1435 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0653 | 0.1435 | 0.5 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0653 | 0.1435 | 0.5 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0701 | 0.1561 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0653 | 0.1435 | 0.5 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0653 | 0.1435 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0653 | 0.1435 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0653 | 0.1435 | 0.5 |
Plasmodium falciparum | esterase, putative | 0.0653 | 0.1435 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0752 | 0.1698 | 1 |
Leishmania major | monoglyceride lipase, putative | 0.0653 | 0.1435 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0752 | 0.1698 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0653 | 0.1435 | 0.5 |
Plasmodium vivax | PST-A protein | 0.0653 | 0.1435 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0653 | 0.1435 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0653 | 0.1435 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0653 | 0.1435 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0752 | 0.1698 | 1 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0653 | 0.1435 | 0.5 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.387 | 1 | 1 |
Onchocerca volvulus | Deterin homolog | 0.0114 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2 nM | Cytotoxicity against human MDA-MB-231 cells after 4 days by MTS assay | ChEMBL. | 25278234 |
IC50 (binding) | = 79 nM | Inhibition of cIAP1 BIR2-3 (unknown origin) assessed as inhibition of polarization activity using N-His-Tb-cBir2-3(154-352) by fluorescence polarization assay | ChEMBL. | 25278234 |
IC50 (binding) | = 100 nM | Inhibition of XIAP-BIR3 (unknown origin) by HTRF assay | ChEMBL. | 25278234 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 25278234 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.