Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nischarin | 0.0162637 | 0.0288158 | 0.0288158 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0789141 | 0.224282 | 0.259277 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0848891 | 0.242924 | 0.242924 |
Plasmodium vivax | kinesin-5 | 0.0432599 | 0.113043 | 1 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0432599 | 0.113043 | 0.195757 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.192115 | 0.577465 | 1 |
Brugia malayi | Dopamine receptor protein 1 | 0.058127 | 0.159427 | 0.276082 |
Leishmania major | C-8 sterol isomerase-like protein | 0.192115 | 0.577465 | 1 |
Plasmodium falciparum | kinesin-5 | 0.0432599 | 0.113043 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.0432599 | 0.113043 | 0.130681 |
Schistosoma mansoni | hypothetical protein | 0.284285 | 0.865031 | 1 |
Echinococcus granulosus | nischarin | 0.0162637 | 0.0288158 | 0.0288158 |
Entamoeba histolytica | kinesin, putative | 0.0432599 | 0.113043 | 0.5 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0432599 | 0.113043 | 1 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0789141 | 0.224282 | 0.224282 |
Echinococcus multilocularis | kinesin family 1 | 0.327545 | 1 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.00702777 | 0 | 0.5 |
Onchocerca volvulus | Nischarin homolog | 0.0157833 | 0.027317 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0432599 | 0.113043 | 0.5 |
Echinococcus granulosus | kinesin family 1 | 0.327545 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.192115 | 0.577465 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.192115 | 0.577465 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.192115 | 0.577465 | 1 |
Brugia malayi | Kinesin motor domain containing protein | 0.0432599 | 0.113043 | 0.195757 |
Loa Loa (eye worm) | hypothetical protein | 0.058127 | 0.159427 | 0.276082 |
Brugia malayi | hypothetical protein | 0.0157833 | 0.027317 | 0.047305 |
Schistosoma mansoni | amine GPCR | 0.0780757 | 0.221666 | 0.256252 |
Loa Loa (eye worm) | hypothetical protein | 0.0986491 | 0.285854 | 0.495016 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0848891 | 0.242924 | 0.242924 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0789141 | 0.224282 | 0.224282 |
Loa Loa (eye worm) | hypothetical protein | 0.0157833 | 0.027317 | 0.047305 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.37 uM | Antimalarial activity against Plasmodium falciparum FCR3 after 48 hrs by parasite lactate dehydrogenase assay | ChEMBL. | 25255435 |
IC50 (functional) | > 100 uM | Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay | ChEMBL. | 25255435 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 25255435 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.