Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, delta 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cdc2-related kinase 3 | 0.0095 | 0.0019 | 0.5 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0095 | 0.0019 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0095 | 0.0019 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0095 | 0.0019 | 1 |
Plasmodium falciparum | protein kinase 5 | 0.0095 | 0.0019 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0095 | 0.0019 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0095 | 0.0019 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0095 | 0.0019 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0095 | 0.0019 | 0.5 |
Mycobacterium ulcerans | O-methyltransferase | 0.0591 | 0.9218 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0095 | 0.0019 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0095 | 0.0019 | 0.5 |
Mycobacterium tuberculosis | Probable catechol-O-methyltransferase | 0.053 | 0.808 | 0.5 |
Brugia malayi | cell division control protein 2 homolog | 0.0095 | 0.0019 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0095 | 0.0019 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0095 | 0.0019 | 0.5 |
Plasmodium vivax | protein kinase Crk2 | 0.0095 | 0.0019 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0095 | 0.0019 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0634 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0095 | 0.0019 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0095 | 0.0019 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0095 | 0.0019 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0095 | 0.0019 | 0.5 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0095 | 0.0019 | 0.5 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0095 | 0.0019 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0095 | 0.0019 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0095 | 0.0019 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0095 | 0.0019 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 7020 nM | Displacement of [125I]IOXY from human kappa opioid receptor expressed in CHO cells | ChEMBL. | 17580847 |
Ki (binding) | > 10000 nM | Displacement of [125I]IOXY from human mu opioid receptor expressed in CHO cells | ChEMBL. | 17580847 |
Ki (binding) | > 10000 nM | Displacement of [125I]IOXY from human delta opioid receptor expressed in CHO cells | ChEMBL. | 17580847 |
Ki (functional) | > 1.9 uM | Antagonist activity at kappa opioid receptor by [35S]GTPgammaS binding assay | ChEMBL. | 19099466 |
Ki (functional) | > 1.9 uM | Antagonist activity at mu opioid receptor (unknown origin) by [35S]GTPgammaS binding assay | ChEMBL. | 23548164 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.