Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0107 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0107 | 0.5 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0107 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0107 | 0.5 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0107 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0107 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0107 | 0.5 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0107 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0107 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0107 | 0.5 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0107 | 0.5 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0107 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0107 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0107 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0107 | 0.5 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0107 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Displacement (binding) | = 25 % | Percentage displacement of [3H]-CGS- 21680 from Adenosine A2A receptor of rat striatal membranes at 10 uM | ChEMBL. | 10212125 |
Displacement (binding) | = 31 % | Percentage displacement of [3H]-DPCPX from rat cortical membranes Adenosine A1 receptor at 10 uM | ChEMBL. | 10212125 |
EC50 (functional) | = 473 nM | Effective concentration for stimulation of [35S]-GTP-gammaS, binding to human adenosine A3 receptor | ChEMBL. | 10212125 |
Inhibition (functional) | = 60 % | Inhibition of forskolin-stimulated cAMP production mediated by human adenosine A3 receptor expressed in CHO cells at 10 uM | ChEMBL. | 10212125 |
Inhibition (functional) | = 93 % | Inhibiion of forskolin-induced c-AMP production by adenosine A3 receptor with 10 uM NECA | ChEMBL. | 10212125 |
Ki (binding) | = 128 nM | Binding affinity athuman Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB-MECA displacement. | ChEMBL. | 10212125 |
Radioligand bound (functional) | = 52 % | Percentage of [35S]-GTP-gammaS, binding to the human adenosine A3 receptor stimulated at 10E-4 M | ChEMBL. | 10212125 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.