Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | kinesin eg-5 | 0.0519 | 0.123 | 0.1415 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0239 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0092 | 0.0748 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0126 | 0.0239 | 0.1944 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0126 | 0.0239 | 0.1944 |
Schistosoma mansoni | hypothetical protein | 0.0338 | 0.0773 | 0.0889 |
Schistosoma mansoni | hypothetical protein | 0.0338 | 0.0773 | 0.0889 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.0092 | 0.0748 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0092 | 0.0106 |
Brugia malayi | TAR-binding protein | 0.0126 | 0.0239 | 0.1944 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.0171 | 0.1393 |
Brugia malayi | Kinesin motor domain containing protein | 0.0519 | 0.123 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0171 | 0.1393 |
Loa Loa (eye worm) | RNA binding protein | 0.0126 | 0.0239 | 0.1944 |
Entamoeba histolytica | kinesin, putative | 0.0519 | 0.123 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0126 | 0.0239 | 0.0239 |
Echinococcus granulosus | geminin | 0.0338 | 0.0773 | 0.0773 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0239 | 0.0275 |
Echinococcus multilocularis | kinesin family 1 | 0.3994 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.0171 | 0.1393 |
Echinococcus granulosus | tar DNA binding protein | 0.0126 | 0.0239 | 0.0239 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0239 | 0.0275 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0239 | 0.0275 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0239 | 0.0275 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0519 | 0.123 | 1 |
Giardia lamblia | Kinesin-5 | 0.0519 | 0.123 | 0.5 |
Plasmodium falciparum | kinesin-5 | 0.0519 | 0.123 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.3475 | 0.8691 | 1 |
Plasmodium vivax | kinesin-5 | 0.0519 | 0.123 | 0.5 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0519 | 0.123 | 0.5 |
Brugia malayi | RNA binding protein | 0.0126 | 0.0239 | 0.1944 |
Echinococcus multilocularis | geminin | 0.0338 | 0.0773 | 0.0773 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.0171 | 0.1393 |
Loa Loa (eye worm) | TAR-binding protein | 0.0126 | 0.0239 | 0.1944 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 90 uM | Inhibition of Staphylococcus aureus DNA gyrase assessed as reduction in enzyme-catalyzed supercoiling of relaxed circular pBR322 DNA by agarose gel electrophoresis | ChEMBL. | 25238555 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.