Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutamate receptor | 0.005 | 0.0117 | 0.095 |
Plasmodium vivax | kinesin-5 | 0.0337 | 0.1233 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0162 | 0.1312 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0337 | 0.1233 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0042 | 0.0086 | 0.0078 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.005 | 0.0117 | 0.0815 |
Plasmodium falciparum | kinesin-5 | 0.0337 | 0.1233 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0337 | 0.1233 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.2255 | 0.8691 | 1 |
Brugia malayi | Kinesin motor domain containing protein | 0.0337 | 0.1233 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.2592 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0061 | 0.0162 | 0.0077 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0337 | 0.1233 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.0337 | 0.1233 | 0.1401 |
Entamoeba histolytica | kinesin, putative | 0.0337 | 0.1233 | 0.5 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0045 | 0.0099 | 0.0665 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.0144 | 0.0145 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0061 | 0.0162 | 0.0077 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Displacement (binding) | = 9.3 % | Displacement of [3H]-N-methylscopolamine ([3H]-NMS) binding at muscarinic acetylcholine receptor in rat cerebral cortical membranes | ChEMBL. | 1848294 |
Displacement (binding) | = 22.3 % | Evaluated for displacement of [3H]-oxotremorine-M binding ([3H]-OXO-M) at muscarinic acetylcholine receptor in rat forebrain membranes | ChEMBL. | 1848294 |
Inhibition (functional) | % | The percent inhibition of cyclic AMP(cAMP) formation in NG108-15 cells expressed in m40AChR was measured; i=inactive (< 2%) | ChEMBL. | 1848294 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.