Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0212 | 0.2779 | 0.1975 | |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0642 | 0.2309 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0193 | 0.2498 | 0.5 |
Onchocerca volvulus | 0.0212 | 0.2779 | 0.1975 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0122 | 0.1456 | 0.5239 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1002 | 0.3604 |
Giardia lamblia | Telomerase catalytic subunit | 0.0193 | 0.2498 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0212 | 0.2779 | 0.387 |
Onchocerca volvulus | 0.0212 | 0.2779 | 0.1975 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0212 | 0.2779 | 0.387 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.2779 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0122 | 0.1456 | 0.5239 |
Brugia malayi | Telomerase reverse transcriptase | 0.0513 | 0.7181 | 1 |
Brugia malayi | hypothetical protein | 0.009 | 0.1002 | 0.1395 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0193 | 0.2498 | 0.5 |
Brugia malayi | hypothetical protein | 0.0122 | 0.1456 | 0.2028 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1002 | 0.3604 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0083 | 0.089 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0193 | 0.2498 | 0.5 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0212 | 0.2779 | 1 |
Brugia malayi | LBP/BPI | 0.009 | 0.1002 | 0.1395 |
Onchocerca volvulus | 0.0122 | 0.1456 | 0.0505 | |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.1456 | 0.5239 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.1456 | 0.5239 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0212 | 0.2779 | 0.387 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0083 | 0.089 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0076 | 0.0788 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0193 | 0.2498 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1002 | 0.3604 |
Onchocerca volvulus | 0.0212 | 0.2779 | 0.1975 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0122 | 0.1456 | 0.2028 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0076 | 0.0788 | 1 |
Onchocerca volvulus | 0.0212 | 0.2779 | 0.1975 | |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.1456 | 0.5239 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1002 | 0.3604 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0193 | 0.2498 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.009 | 0.1002 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0193 | 0.2498 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0076 | 0.0788 | 0.2836 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0122 | 0.1456 | 0.2028 |
Onchocerca volvulus | 0.0212 | 0.2779 | 0.1975 | |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.1456 | 0.5239 |
Onchocerca volvulus | 0.0122 | 0.1456 | 0.0505 | |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0076 | 0.0788 | 0.1098 |
Brugia malayi | hypothetical protein | 0.0122 | 0.1456 | 0.2028 |
Onchocerca volvulus | 0.0212 | 0.2779 | 0.1975 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0122 | 0.1456 | 0.2028 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0193 | 0.2498 | 0.5 |
Onchocerca volvulus | 0.0212 | 0.2779 | 0.1975 | |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.1456 | 0.5239 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.