Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0089 | 0.0491 | 0.0448 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0089 | 0.0491 | 0.0448 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.0089 | 0.0491 | 0.0448 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0089 | 0.0491 | 0.0491 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0036 | 0.0023 | 0.5 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0242 | 0.1848 | 0.1848 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0946 | 0.8067 | 1 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0242 | 0.1848 | 0.2248 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0153 | 0.1062 | 0.1022 |
Echinococcus multilocularis | tyrosine kinase | 0.0089 | 0.0491 | 0.0448 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0089 | 0.0491 | 0.0448 |
Schistosoma mansoni | tyrosine kinase | 0.0089 | 0.0491 | 0.0454 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0089 | 0.0491 | 0.0448 |
Trypanosoma cruzi | extracellular receptor, putative | 0.0089 | 0.0491 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0089 | 0.0491 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0491 | 0.0491 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.1848 | 0.1848 |
Entamoeba histolytica | hypothetical protein | 0.0089 | 0.0491 | 0.5 |
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.0089 | 0.0491 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0491 | 0.0491 |
Brugia malayi | hypothetical protein | 0.0089 | 0.0491 | 0.0556 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0089 | 0.0491 | 0.0491 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0242 | 0.1848 | 0.1848 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0089 | 0.0491 | 0.0491 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0089 | 0.0491 | 0.0448 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0036 | 0.0023 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0089 | 0.0491 | 0.0454 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0153 | 0.1062 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0089 | 0.0491 | 0.0448 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0857 | 0.7281 | 0.902 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0491 | 0.0491 |
Loa Loa (eye worm) | glutamate receptor | 0.0946 | 0.8067 | 0.8067 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0089 | 0.0491 | 0.0448 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0089 | 0.0491 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.1164 | 1 | 1 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0153 | 0.1062 | 0.1268 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0089 | 0.0491 | 0.0448 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0792 | 0.671 | 0.726 |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.0089 | 0.0491 | 0.0448 |
Echinococcus granulosus | tyrosine kinase | 0.0089 | 0.0491 | 0.0448 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.0089 | 0.0491 | 0.0448 |
Echinococcus granulosus | glutamate receptor 2 | 0.0089 | 0.0491 | 0.0448 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.1075 | 0.9214 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0461 | 0.3781 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1062 | 0.1062 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0792 | 0.671 | 0.6695 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0089 | 0.0491 | 0.0448 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0089 | 0.0491 | 0.0556 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0153 | 0.1062 | 0.1022 |
Schistosoma mansoni | tyrosine kinase | 0.0089 | 0.0491 | 0.0454 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0089 | 0.0491 | 0.0454 |
Loa Loa (eye worm) | metabotropic glutamate receptor 8 | 0.0089 | 0.0491 | 0.0491 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0491 | 0.0491 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0153 | 0.1062 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0372 | 0.2994 | 0.2994 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0089 | 0.0491 | 0.0448 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0089 | 0.0491 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0491 | 0.0491 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0792 | 0.671 | 0.6695 |
Schistosoma mansoni | hypothetical protein | 0.0153 | 0.1062 | 0.1079 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0461 | 0.3781 | 0.4657 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0491 | 0.0491 |
Brugia malayi | Guanylyl cyclase protein 23 | 0.0089 | 0.0491 | 0.0556 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0491 | 0.0491 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.1164 | 1 | 1 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0089 | 0.0491 | 0.0556 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0038 | 0.0045 | 0.0045 |
Leishmania major | extracellular receptor, putative | 0.0089 | 0.0491 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 17 uM | Concentration required to reduce the viability of mock infected cells by 50% | ChEMBL. | 8568797 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.