Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | histone deacetylase hda2 | 0.0101 | 0.0171 | 0.3371 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0235 | 0.0509 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0171 | 0.3371 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0235 | 0.0509 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0235 | 0.0509 | 1 |
Echinococcus granulosus | histone deacetylase | 0.0212 | 0.045 | 0.8842 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0235 | 0.0509 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0212 | 0.045 | 0.8842 |
Echinococcus granulosus | histone deacetylase 1 | 0.0235 | 0.0509 | 1 |
Giardia lamblia | Histone deacetylase | 0.0235 | 0.0509 | 1 |
Leishmania major | udp-glc 4-epimerase, putative | 0.0049 | 0.004 | 0.0205 |
Loa Loa (eye worm) | histone deacetylase | 0.0212 | 0.045 | 0.8842 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0196 | 0.3845 |
Schistosoma mansoni | N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase | 0.0045 | 0.0031 | 0.0602 |
Brugia malayi | Disco-interacting protein 2 homolog | 0.0038 | 0.0012 | 0.0244 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0212 | 0.045 | 0.8842 |
Entamoeba histolytica | histone deacetylase, putative | 0.0235 | 0.0509 | 1 |
Echinococcus granulosus | UDP glucose 4 epimerase | 0.0051 | 0.0045 | 0.0883 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0235 | 0.0509 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0212 | 0.045 | 0.8842 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0235 | 0.0509 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0235 | 0.0509 | 1 |
Toxoplasma gondii | UDP-glucose 4-epimerase | 0.0051 | 0.0045 | 0.0299 |
Trypanosoma brucei | UDP-galactose 4-epimerase | 0.0049 | 0.004 | 0.0205 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0212 | 0.045 | 0.8768 |
Trypanosoma cruzi | UDP-galactose 4-epimerase | 0.0051 | 0.0045 | 0.0299 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0235 | 0.0509 | 1 |
Echinococcus granulosus | histone deacetylase 8 | 0.0101 | 0.0171 | 0.3371 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0235 | 0.0509 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0083 | 0.0126 | 0.2001 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0211 | 0.4144 |
Echinococcus granulosus | disco interacting protein 2 | 0.0038 | 0.0012 | 0.0244 |
Plasmodium vivax | histone deacetylase, putative | 0.0212 | 0.045 | 0.8768 |
Leishmania major | histone deacetylase, putative | 0.0212 | 0.045 | 0.8768 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0235 | 0.0509 | 1 |
Plasmodium falciparum | histone deacetylase 2 | 0.0212 | 0.045 | 0.8768 |
Echinococcus granulosus | histone deacetylase 6 | 0.0218 | 0.0465 | 0.9142 |
Giardia lamblia | UDP-glucose 4-epimerase | 0.0049 | 0.004 | 0.0205 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0101 | 0.0171 | 0.3371 |
Echinococcus granulosus | histone deacetylase 6 | 0.0212 | 0.045 | 0.8842 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0218 | 0.0465 | 0.9142 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0012 | 0.0244 |
Echinococcus multilocularis | UDP glucose 4 epimerase | 0.0051 | 0.0045 | 0.0883 |
Schistosoma mansoni | UDP-glucose 4-epimerase | 0.0051 | 0.0045 | 0.0883 |
Trypanosoma brucei | histone deacetylase 3 | 0.0212 | 0.045 | 0.8768 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0235 | 0.0509 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0212 | 0.045 | 0.8842 |
Echinococcus multilocularis | disco interacting protein 2 | 0.0038 | 0.0012 | 0.0244 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0101 | 0.0171 | 1 |
Leishmania major | histone deacetylase, putative | 0.0235 | 0.0509 | 1 |
Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.0051 | 0.0045 | 0.0299 |
Trypanosoma brucei | histone deacetylase 2 | 0.0101 | 0.0171 | 0.2946 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0212 | 0.045 | 0.8768 |
Trypanosoma brucei | histone deacetylase 4 | 0.0212 | 0.045 | 0.8768 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0101 | 0.0171 | 0.3371 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0235 | 0.0509 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0235 | 0.0509 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0235 | 0.0509 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0235 | 0.0509 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0235 | 0.0509 | 1 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0235 | 0.0509 | 1 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0101 | 0.0171 | 0.3371 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0212 | 0.045 | 0.8768 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0235 | 0.0509 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0101 | 0.0171 | 0.2946 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0212 | 0.045 | 0.8842 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0101 | 0.0171 | 0.2946 |
Brugia malayi | Uncharacterized LmbE-like protein, COG2120 containing protein | 0.0045 | 0.0031 | 0.0602 |
Trypanosoma brucei | histone deacetylase, putative | 0.0212 | 0.045 | 0.8768 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0218 | 0.0465 | 0.9142 |
Echinococcus multilocularis | N acetylglucosaminyl phosphatidylinositol | 0.0045 | 0.0031 | 0.0602 |
Echinococcus granulosus | N acetylglucosaminyl phosphatidylinositol | 0.0045 | 0.0031 | 0.0602 |
Plasmodium falciparum | histone deacetylase 1 | 0.0235 | 0.0509 | 1 |
Trypanosoma brucei | histone deacetylase 1 | 0.0235 | 0.0509 | 1 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0101 | 0.0171 | 0.2946 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0101 | 0.0171 | 0.2946 |
Schistosoma mansoni | disco-interacting protein 2 (dip2) | 0.0038 | 0.0012 | 0.0244 |
Trichomonas vaginalis | UDP-glucose 4-epimerase, putative | 0.0051 | 0.0045 | 0.0299 |
Leishmania major | histone deacetylase, putative | 0.0235 | 0.0509 | 1 |
Echinococcus multilocularis | histone deacetylase | 0.0212 | 0.045 | 0.8842 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0235 | 0.0509 | 1 |
Loa Loa (eye worm) | phosphatidylinositol glycan anchor biosynthesis protein | 0.0045 | 0.0031 | 0.0602 |
Brugia malayi | histone deacetylase 11 | 0.0101 | 0.0171 | 0.3371 |
Mycobacterium ulcerans | mycothiol conjugate amidase Mca | 0.4012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.0509 | 1 |
Brugia malayi | UDP galactose 4'-epimerase | 0.0051 | 0.0045 | 0.0883 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0235 | 0.0509 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0235 | 0.0509 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0235 | 0.0509 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0212 | 0.045 | 0.8768 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0212 | 0.045 | 0.8842 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0212 | 0.045 | 0.8768 |
Mycobacterium tuberculosis | Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) | 0.3967 | 0.9887 | 1 |
Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.0051 | 0.0045 | 0.0299 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0083 | 0.0126 | 0.2001 |
Leishmania major | histone deacetylase, putative | 0.0212 | 0.045 | 0.8768 |
Entamoeba histolytica | UDP-glucose 4-epimerase, putative | 0.0051 | 0.0045 | 0.0299 |
Trypanosoma cruzi | UDP-galactose 4-epimerase, putative | 0.0051 | 0.0045 | 0.0299 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0235 | 0.0509 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0212 | 0.045 | 0.8842 |
Echinococcus granulosus | histone deacetylase 6 | 0.0212 | 0.045 | 0.8842 |
Echinococcus granulosus | histone deacetylase 7 | 0.0212 | 0.045 | 0.8842 |
Plasmodium vivax | histone deacetylase, putative | 0.0101 | 0.0171 | 0.2946 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0212 | 0.045 | 0.8842 |
Schistosoma mansoni | histone deacetylase | 0.0235 | 0.0509 | 1 |
Loa Loa (eye worm) | UDP galactose 4'-epimerase | 0.0051 | 0.0045 | 0.0883 |
Onchocerca volvulus | 0.0038 | 0.0012 | 0.0723 | |
Plasmodium falciparum | histone deacetylase, putative | 0.0212 | 0.045 | 0.8768 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.03 mg kg-1 | Tested for beta2 adrenoceptor blocking activity in anesthetized pigs (n=2) challenged with intravenous injections of isoproterenol. | ChEMBL. | 2435902 |
ED50 (functional) | = 0.44 mg kg-1 | Tested for beta1 adrenoceptor blocking activity in anesthetized pigs (n=2) challenged with intravenous injections of isoproterenol. | ChEMBL. | 2435902 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.