Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | myosin xvIII | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0123 | 0.0897 | 0.3061 |
Echinococcus multilocularis | high voltage activated calcium channel beta | 0.0144 | 0.1203 | 0.4104 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0286 | 0.3249 | 1 |
Schistosoma mansoni | opsin-like receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | neuropeptide receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | g protein coupled receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | g-protein coupled receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | opsin-like receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | amine GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | g-protein coupled receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | opsin-like receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | neuropeptide receptor | 0.0264 | 0.2932 | 1 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0085 | 0.0352 | 0.1202 |
Brugia malayi | Voltage-dependent L-type calcium channel beta-2 subunit | 0.0297 | 0.3413 | 0.3173 |
Brugia malayi | Cation transporter family protein | 0.0123 | 0.0897 | 0.0565 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | neuropeptide receptor | 0.0264 | 0.2932 | 1 |
Schistosoma mansoni | amine GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | fmrfamide receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | serotonin receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | hypothetical protein | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Onchocerca volvulus | 0.0123 | 0.0897 | 1 | |
Echinococcus granulosus | high voltage activated calcium channel beta | 0.0144 | 0.1203 | 0.4104 |
Echinococcus granulosus | orexin receptor type 2 | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | g protein coupled receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | hypothetical protein | 0.0085 | 0.0352 | 0.1202 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0647 | 0.0305 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0897 | 0.0565 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | hypothetical protein | 0.0085 | 0.0352 | 0.1202 |
Onchocerca volvulus | 0.0123 | 0.0897 | 1 | |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.0085 | 0.0352 | 0.1202 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0754 | 1 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0085 | 0.0352 | 0.1202 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | neuropeptide receptor | 0.0085 | 0.0352 | 0.1202 |
Loa Loa (eye worm) | hypothetical protein | 0.0754 | 1 | 1 |
Echinococcus granulosus | G protein coupled receptor 139 | 0.0085 | 0.0352 | 0.1202 |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 0.4681 | 0.4487 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | g protein coupled receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | histamine h1 receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | hypothetical protein | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | fmrfamide receptor | 0.0085 | 0.0352 | 0.1202 |
Onchocerca volvulus | 0.0123 | 0.0897 | 1 | |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | g protein coupled receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | serotonin receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | allatostatin A receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | adenoreceptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0123 | 0.0897 | 0.3061 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0286 | 0.3249 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0754 | 1 | 0.5 |
Echinococcus granulosus | allatostatin A receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | amine GPCR | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | 7TM GPCR rhodopsin | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | neuropeptide receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | 7tm_1 domain containing protein | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | neuropeptide s receptor | 0.0085 | 0.0352 | 0.1202 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0754 | 1 | 1 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | serotonin receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | biogenic amine receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | peptide allatostatin:somatostatin | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | neuropeptide receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | orexin receptor type 2 | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | sex peptide receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | biogenic amine receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | somatostatin receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | high voltage-activated calcium channel beta subunit 2 | 0.0144 | 0.1203 | 0.4104 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | biogenic amine receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | alpha 1A adrenergic receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | hypothetical protein | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | somatostatin receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | amine GPCR | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | neuropeptide receptor | 0.0264 | 0.2932 | 1 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.0085 | 0.0352 | 0.1202 |
Brugia malayi | Serotonin receptor | 0.0551 | 0.7071 | 0.6964 |
Echinococcus granulosus | dro:myosuppressin receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | neuropeptide receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | sex peptide receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0085 | 0.0352 | 0.1202 |
Loa Loa (eye worm) | voltage-dependent calcium channel beta 2a subunit | 0.0297 | 0.3413 | 0.3173 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | fmrfamide receptor | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | g protein coupled receptor | 0.0085 | 0.0352 | 0.1202 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0897 | 0.0565 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0085 | 0.0352 | 0.1202 |
Schistosoma mansoni | amine GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0085 | 0.0352 | 0.1202 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0085 | 0.0352 | 0.1202 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0264 | 0.2932 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of human Cav2.2 alpha1B/alpha2delta1/beta3 channel expressed in HEK293 cells assessed as inhibition of depolarization-activated Ba2+ current at 1 uM by whole cell patch clamp technique relative to control | ChEMBL. | 25393758 | |
Inhibition (binding) | Inhibition of human GABAB R1/R2 receptor expressed in HEK293 cells co-expressing human Cav2.2 alpha1B/alpha2delta1/beta3 channel assessed as inhibition of depolarization-activated Ba2+ current by whole cell patch clamp technique relative to control | ChEMBL. | 25393758 | |
Inhibition (binding) | Inhibition of human GABAB R1/R2 receptor expressed in HEK293 cells co-expressing human Cav2.2 alpha1B/alpha2delta1/beta3 channel assessed as inhibition of depolarization-activated Ba2+ current at 50 uM followed by compound washout by whole cell patch clamp technique relative to control | ChEMBL. | 25393758 | |
Inhibition (binding) | Inhibition of N-type Ca channel in Wistar rat DRG neuron at 100 nM by whole cell patch clamp technique relative to control | ChEMBL. | 25393758 | |
Inhibition (binding) | Inhibition of human GABAB R1/R2 receptor expressed in HEK293 cells co-expressing human Cav2.2 alpha1B/alpha2delta1/beta3 channel assessed as inhibition of depolarization-activated Ba2+ current at 1 uM followed by compound washout by whole cell patch clamp technique relative to control | ChEMBL. | 25393758 | |
Inhibition (binding) | Inhibition of human GABAB R1/R2 receptor expressed in HEK293 cells co-expressing human Cav2.2 alpha1B/alpha2delta1/beta3 channel assessed as inhibition of depolarization-activated Ba2+ current depolarization-activated Ba2+ current at 50 uM by whole cell patch clamp technique relative to control | ChEMBL. | 25393758 | |
Inhibition (binding) | Inhibition of rat alpha9alpha10 nAChR expressed in Xenopus oocytes assessed as inhibition of Ach-evoked current at 30 uM after 5 mins by voltage-clamp technique | ChEMBL. | 25393758 | |
Inhibition (binding) | = 35 % | Inhibition of human GABAB R1/R2 receptor expressed in HEK293 cells co-expressing human Cav2.2 alpha1B/alpha2delta1/beta3 channel assessed as inhibition of depolarization-activated Ba2+ current at 1 uM by whole cell patch clamp technique relative to control | ChEMBL. | 25393758 |
Stabilty (ADMET) | = 30 % | Metabolic stability in human serum assessed as compound remaining at 3 mM after 1 hr by RP-HPLC analysis | ChEMBL. | 25393758 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.