Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | kinesin family 1 | 1.033 | 1 | 1 |
Plasmodium vivax | kinesin-5 | 0.1342 | 0 | 0.5 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.1342 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 1.0024 | 0.9659 | 1 |
Entamoeba histolytica | kinesin, putative | 0.1342 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.8988 | 0.8507 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3226 | 0.2097 | 0.2465 |
Onchocerca volvulus | 0.3226 | 0.2097 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 1.0024 | 0.9659 | 1 |
Giardia lamblia | Kinesin-5 | 0.1342 | 0 | 0.5 |
Plasmodium falciparum | kinesin-5 | 0.1342 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | > 80 % | Cytotoxicity against human HaCaT cells assessed as cell viability at 100 ug/ml after 18 hrs by MTT assay | ChEMBL. | 24961161 |
MIC (functional) | = 7.5 ug ml-1 | Antibacterial activity against clinical isolates of imipenem-resistant Escherichia coli PGI/DML02292 after overnight incubation by microdilution broth assay | ChEMBL. | 24961161 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.