Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0039 | 0.0033 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.5842 | 1 | 1 |
Loa Loa (eye worm) | calcium channel | 0.0318 | 0.0399 | 0.0546 |
Schistosoma mansoni | voltage-gated cation channel | 0.0318 | 0.0399 | 0.0917 |
Brugia malayi | Matrixin family protein | 0.1398 | 0.2277 | 0.2828 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0098 | 0.0017 | 0.0061 |
Brugia malayi | Matrixin family protein | 0.1398 | 0.2277 | 0.2828 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0111 | 0.0039 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.118 | 0.1898 | 0.499 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0098 | 0.0017 | 0.0061 |
Brugia malayi | Matrixin family protein | 0.4138 | 0.704 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.3101 | 0.5237 | 0.7434 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0111 | 0.0039 | 0.5 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0111 | 0.0039 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1398 | 0.2277 | 0.3219 |
Schistosoma mansoni | hypothetical protein | 0.1898 | 0.3145 | 0.8378 |
Brugia malayi | Matrixin family protein | 0.1398 | 0.2277 | 0.2828 |
Brugia malayi | Hemopexin family protein | 0.1898 | 0.3145 | 0.4134 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.1703 | 0.2807 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1703 | 0.2807 | 0.3973 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0098 | 0.0017 | 0.0061 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0318 | 0.0399 | 0.0917 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.1703 | 0.2807 | 0.3625 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.3101 | 0.5237 | 0.669 |
Onchocerca volvulus | Matrilysin homolog | 0.3944 | 0.6702 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.4138 | 0.704 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2241 | 0.3741 | 0.5304 |
Mycobacterium ulcerans | hydrolase | 0.1703 | 0.2807 | 0.5 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0318 | 0.0399 | 0.0362 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0111 | 0.0039 | 0.0033 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.2241 | 0.3741 | 1 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0318 | 0.0399 | 0.0362 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0318 | 0.0399 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.1398 | 0.2277 | 0.3219 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0318 | 0.0399 | 0.0362 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.1703 | 0.2807 | 1 |
Onchocerca volvulus | 0.1898 | 0.3145 | 0.1961 | |
Loa Loa (eye worm) | hypothetical protein | 0.0318 | 0.0399 | 0.0546 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.1398 | 0.2277 | 0.3219 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0098 | 0.0017 | 0.0061 |
Brugia malayi | Matrixin family protein | 0.1398 | 0.2277 | 0.2828 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0318 | 0.0399 | 0.0917 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 416 nM | Agonist activity at human recombinant CB2 receptor expressing CHO cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins | ChEMBL. | 25575658 |
EC50 (functional) | > 20000 nM | Agonist activity at human recombinant CB1 receptor expressing CHO cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins | ChEMBL. | 25575658 |
T1/2 (ADMET) | > 120 min | Half life in human liver microsomes at 1 uM in presence of NADPH by LC-MS/MS method | ChEMBL. | 25575658 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.