Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 2, subfamily A, polypeptide 6 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 2, subfamily A, polypeptide 6 | 494 aa | 485 aa | 32.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | cyclins, putative | 0.011 | 0.3839 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0082 | 0.2069 | 0.539 |
Leishmania major | cyclin | 0.011 | 0.3839 | 0.5 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.011 | 0.3839 | 1 |
Trypanosoma cruzi | cyclin 6, putative | 0.011 | 0.3839 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0082 | 0.2069 | 0.539 |
Trichomonas vaginalis | cyclin B, putative | 0.011 | 0.3839 | 1 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0209 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0062 | 0.0848 | 0.5 |
Trichomonas vaginalis | cyclin D, putative | 0.0082 | 0.2069 | 0.539 |
Trichomonas vaginalis | cyclin B, putative | 0.011 | 0.3839 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0082 | 0.2069 | 0.539 |
Trichomonas vaginalis | cyclin B, putative | 0.011 | 0.3839 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.011 | 0.3839 | 1 |
Trypanosoma brucei | mitotic cyclin 6 | 0.011 | 0.3839 | 0.5 |
Trichomonas vaginalis | cyclin B3, putative | 0.0082 | 0.2069 | 0.539 |
Onchocerca volvulus | 0.011 | 0.3839 | 0.5 | |
Trypanosoma cruzi | cyclin, putative | 0.011 | 0.3839 | 0.5 |
Trichomonas vaginalis | cyclin A, putative | 0.011 | 0.3839 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.011 | 0.3839 | 1 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0209 | 1 | 1 |
Echinococcus multilocularis | cyclin B | 0.011 | 0.3839 | 0.2232 |
Schistosoma mansoni | cyclin B3 | 0.0209 | 1 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0082 | 0.2069 | 0.539 |
Echinococcus granulosus | cyclin B | 0.011 | 0.3839 | 0.2232 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0209 | 1 | 1 |
Entamoeba histolytica | cyclin, putative | 0.011 | 0.3839 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.011 | 0.3839 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.011 | 0.3839 | 1 |
Plasmodium falciparum | cyclin | 0.0082 | 0.2069 | 0.5 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.011 | 0.3839 | 0.5 |
Trypanosoma cruzi | cyclin, putative | 0.011 | 0.3839 | 0.5 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.011 | 0.3839 | 0.5 |
Schistosoma mansoni | cyclin B | 0.011 | 0.3839 | 0.2232 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.9 uM | Inhibition of human CYP2A6 in baculovirus-infected insect cell system using coumarin 7 as substrate preincubated for 10 mins by fluorescence assay | ChEMBL. | 25458499 |
Inhibition (binding) | Inhibition of human CYP2A6 in baculovirus-infected insect cell system using coumarin 7 as substrate incubated for 30 mins prior to substrate addition measured after 10 mins by fluorescence assay | ChEMBL. | 25458499 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.