Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | voltage-gated potassium channel | 0.1691 | 0 | 0.5 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.1714 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.1714 | 1 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.1714 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of recombinant N-terminal His6-tagged KIFC1 (Q305-K673 aa) (unknown origin) expressed in Escherichia coli BL21 (DE3) by malachite green assay | ChEMBL. | 25458601 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.