Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MDM2 proto-oncogene, E3 ubiquitin protein ligase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0013 | 0 | 0.5 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0013 | 0 | 0.5 |
Chlamydia trachomatis | SWIB complex protein | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0013 | 0 | 0.5 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0013 | 0 | 0.5 |
Mycobacterium ulcerans | transcriptional regulatory protein | 0.0059 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | brahma associated protein | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0013 | 0 | 0.5 |
Mycobacterium tuberculosis | Transcriptional regulatory protein (probably AraC-family) | 0.0059 | 1 | 0.5 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0013 | 0 | 0.5 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0013 | 0 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.0013 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0 | 0.5 |
Mycobacterium ulcerans | AraC/XylS family transcriptional regulator | 0.0059 | 1 | 0.5 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0013 | 0 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0013 | 0 | 0.5 |
Mycobacterium tuberculosis | Transcriptional regulatory protein | 0.0059 | 1 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | brg-1 associated factor | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0013 | 0 | 0.5 |
Mycobacterium ulcerans | Ada regulatory protein AlkA | 0.0059 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein | 0.0059 | 1 | 0.5 |
Mycobacterium ulcerans | transcriptional regulatory protein | 0.0059 | 1 | 0.5 |
Mycobacterium tuberculosis | Virulence-regulating transcriptional regulator VirS (AraC/XylS family) | 0.0059 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.9 uM | Inhibition of MDM2/P53 (unknown origin) protein interaction by fluorescent polarization assay | ChEMBL. | 25479770 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.