Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arginine vasopressin receptor 1B | Starlite/ChEMBL | References |
Homo sapiens | oxytocin receptor | Starlite/ChEMBL | References |
Homo sapiens | arginine vasopressin receptor 1A | Starlite/ChEMBL | References |
Homo sapiens | arginine vasopressin receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0034 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0034 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0034 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0034 | 0.5 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0034 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0034 | 0.5 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0034 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0034 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.07 nM | Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay | ChEMBL. | 24874785 |
EC50 (binding) | = 230 nM | Agonist activity at human vasopressin V2 expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay | ChEMBL. | 24874785 |
EC50 (binding) | > 10000 nM | Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay | ChEMBL. | 24874785 |
EC50 (binding) | > 10000 nM | Agonist activity at human vasopressin V1b expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay | ChEMBL. | 24874785 |
IC50 (binding) | = 1500 nM | Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay | ChEMBL. | 24874785 |
Inhibition (binding) | Antagonist activity at human vasopressin V1b expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay | ChEMBL. | 24874785 | |
Inhibition (binding) | Antagonist activity at human vasopressin V2 expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay | ChEMBL. | 24874785 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.