Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | Get druggable targets OG5_134726 | All targets in OG5_134726 |
Schistosoma japonicum | Serine/threonine-protein kinase PLK4, putative | Get druggable targets OG5_134726 | All targets in OG5_134726 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | Get druggable targets OG5_134726 | All targets in OG5_134726 |
Schistosoma japonicum | Serine/threonine-protein kinase PLK4, putative | Get druggable targets OG5_134726 | All targets in OG5_134726 |
Schistosoma mansoni | kinase | Get druggable targets OG5_134726 | All targets in OG5_134726 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0058 | 0 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0058 | 0 | 0.5 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | 0.0135 | 0.5712 | 0.7127 |
Echinococcus granulosus | geminin | 0.0166 | 0.8015 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0058 | 0 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0058 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0166 | 0.8015 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.8015 | 0.8015 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0058 | 0 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0058 | 0 | 0.5 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0058 | 0 | 0.5 |
Giardia lamblia | Kinase, PLK | 0.0058 | 0 | 0.5 |
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | 0.0135 | 0.5712 | 0.7127 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0058 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.8015 | 0.8015 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0058 | 0 | 0.5 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0058 | 0 | 0.5 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0058 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0058 | 0 | 0.5 |
Trypanosoma brucei | polo-like protein kinase | 0.0058 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0058 | 0 | 0.5 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0058 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.1 uM | Cytotoxicity against human MCF7 cells after 5 days by SRB assay | ChEMBL. | 24867403 |
IC50 (binding) | = 0.79 nM | Inhibition of human N-terminal GST-tagged PLK4 (1 to 391 residues) expressed in Escherichia coli incubated for 30 mins by ELISA method | ChEMBL. | 24867403 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.