Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily A, member 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Transient receptor potential cation channel subfamily V member 4 | Starlite/ChEMBL | References |
Rattus norvegicus | Transient receptor potential cation channel subfamily M member 8 | Starlite/ChEMBL | References |
Homo sapiens | transient receptor potential cation channel, subfamily V, member 4 | Starlite/ChEMBL | References |
Rattus norvegicus | Transient receptor potential cation channel subfamily A member 1 | Starlite/ChEMBL | References |
Homo sapiens | transient receptor potential cation channel, subfamily M, member 8 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | transient receptor potential cation channel | Transient receptor potential cation channel subfamily M member 8 | 1104 aa | 1095 aa | 25.2 % |
Schistosoma mansoni | transient receptor potential cation channel subfamily m member | Transient receptor potential cation channel subfamily M member 8 | 1104 aa | 1070 aa | 24.6 % |
Echinococcus granulosus | transient receptor potential cation channel | Transient receptor potential cation channel subfamily M member 8 | 1104 aa | 1098 aa | 25.1 % |
Echinococcus granulosus | transient receptor potential cation channel | transient receptor potential cation channel, subfamily M, member 8 | 1104 aa | 1115 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.1078 | 0.1272 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.8301 | 1 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0409 | 0.0464 | 0.0464 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.041 | 0.0464 | 0.0464 |
Echinococcus granulosus | ankyrin repeat protein | 0.0384 | 0.0433 | 0.0433 |
Entamoeba histolytica | kinesin, putative | 0.1078 | 0.1272 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0026 | 0.000000007299 | 0.000000007299 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.1078 | 0.1272 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0026 | 0.000000007299 | 0.000000007299 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.0384 | 0.0433 | 0.0498 |
Brugia malayi | Kinesin motor domain containing protein | 0.1078 | 0.1272 | 1 |
Echinococcus multilocularis | ankyrin repeat protein | 0.0384 | 0.0433 | 0.0433 |
Plasmodium vivax | kinesin-5 | 0.1078 | 0.1272 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.7222 | 0.8697 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.1078 | 0.1272 | 0.1463 |
Giardia lamblia | Kinesin-5 | 0.1078 | 0.1272 | 0.5 |
Plasmodium falciparum | kinesin-5 | 0.1078 | 0.1272 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | < 7 ml/min.kg | Intrinsic clearance in human liver microsomes | ChEMBL. | 25455182 |
IC50 (binding) | = 5.8 nM | Antagonist activity at rat TRPM8 assessed as inhibition of menthol induced Ca2+ influx by cell-based assay | ChEMBL. | 25455182 |
IC50 (binding) | = 8.3 nM | Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx | ChEMBL. | 25455182 |
IC50 (binding) | > 3 uM | Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of hypotonic solution-induced Ca2+ influx | ChEMBL. | 25455182 |
IC50 (binding) | > 3 uM | Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx | ChEMBL. | 25455182 |
IC50 (binding) | > 10 uM | Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced Ca2+ influx | ChEMBL. | 25455182 |
IC50 (binding) | > 10 uM | Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced Ca2+ influx | ChEMBL. | 25455182 |
IC50 (binding) | > 10 uM | Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx | ChEMBL. | 25455182 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.