Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.3925 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3802 | 0.9378 | 0.9378 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.3925 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.3802 | 0.9378 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.3925 | 1 | 1 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.3925 | 1 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.3802 | 0.9378 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.3802 | 0.9378 | 0.5 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.3925 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 25 uM | Inhibition of ovine COX-1 assessed as inhibition of [14C]arachidonic acid to radiolabeled prostaglandins preincubated for 15 mins by TLC-based assay | ChEMBL. | 25408841 |
IC50 (binding) | > 25 uM | Inhibition of mouse COX-2 assessed as inhibition of [14C]arachidonic acid to radiolabeled prostaglandins preincubated for 15 mins by TLC-based assay | ChEMBL. | 25408841 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.