Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.1809 | 1 | 1 |
Onchocerca volvulus | 0.0306 | 0.0004 | 1 | |
Echinococcus multilocularis | conserved hypothetical protein | 0.0667 | 0.2404 | 0.2401 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0591 | 0.1903 | 0.1899 |
Brugia malayi | Serotonin receptor | 0.0451 | 0.0972 | 0.0968 |
Onchocerca volvulus | 0.0306 | 0.0004 | 1 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1809 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1809 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0306 | 0.0004 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1809 | 1 | 1 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0323 | 0.0119 | 0.0115 |
Onchocerca volvulus | 0.0306 | 0.0004 | 1 | |
Echinococcus granulosus | hypothetical protein | 0.0674 | 0.245 | 0.2446 |
Onchocerca volvulus | 0.0306 | 0.0004 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.1809 | 1 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.062 | 0.2093 | 0.2089 |
Onchocerca volvulus | 0.0306 | 0.0004 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.1809 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1809 | 1 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0576 | 0.1803 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1809 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1809 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1809 | 1 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0406 | 0.0674 | 0.067 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0366 | 0.0403 | 0.0399 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0323 | 0.0119 | 0.0115 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.062 | 0.2093 | 0.2089 |
Echinococcus multilocularis | acetylcholinesterase | 0.1809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1809 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0366 | 0.0403 | 0.0399 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0306 | 0.0004 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0536 | 0.1533 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0576 | 0.1803 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0406 | 0.0674 | 0.067 |
Schistosoma mansoni | glutamate receptor NMDA | 0.062 | 0.2093 | 0.2089 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 256 ug ml-1 | Antibacterial activity against Escherichia coli CCUGT after 16 to 18 hrs by microbroth dilution method | ChEMBL. | 25455183 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.