Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fatty acid amide hydrolase | Starlite/ChEMBL | References |
Homo sapiens | monoglyceride lipase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | fatty acid amide hydrolase | 579 aa | 471 aa | 26.5 % |
Plasmodium falciparum | esterase, putative | monoglyceride lipase | 303 aa | 254 aa | 19.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0457 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0457 | 1 | 0.5 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0198 | 0.3041 | 1 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0084 | 0 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0457 | 1 | 1 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0198 | 0.3041 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0457 | 1 | 1 |
Plasmodium vivax | PST-A protein | 0.0084 | 0 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0457 | 1 | 1 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0457 | 1 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0457 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0457 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0457 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0198 | 0.3041 | 0.3041 |
Leishmania major | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0457 | 1 | 1 |
Plasmodium falciparum | esterase, putative | 0.0084 | 0 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0457 | 1 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0457 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0457 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0198 | 0.3041 | 0.3041 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0 | 0.5 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0198 | 0.3041 | 0.3041 |
Schistosoma mansoni | glycogen phosphorylase | 0.0198 | 0.3041 | 0.2231 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0457 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0457 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0457 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.78 | Inhibition of human recombinant MAGL expressed in HEK293 cells using 2-AG as substrate | ChEMBL. | 25282655 |
IC50 (binding) | = 6.85 | Inhibition of human recombinant FAAH expressed in COS7 cells using anandamide as substrate | ChEMBL. | 25282655 |
IC50 (binding) | = 141 nM | Inhibition of human recombinant FAAH expressed in COS7 cells using anandamide as substrate | ChEMBL. | 25282655 |
IC50 (binding) | = 1660 nM | Inhibition of human recombinant MAGL expressed in HEK293 cells using 2-AG as substrate | ChEMBL. | 25282655 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.