Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | solute carrier family 12 | 0.0253 | 1 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.007 | 0.1183 | 0.5 |
Loa Loa (eye worm) | amino acid permease | 0.0253 | 1 | 1 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.007 | 0.1183 | 0.1183 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.007 | 0.1183 | 0.1183 |
Trypanosoma cruzi | aminopeptidase, putative | 0.007 | 0.1183 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.8267 | 0.8267 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.007 | 0.1183 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.8267 | 0.8267 |
Echinococcus multilocularis | aminopeptidase N | 0.007 | 0.1183 | 0.1183 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.007 | 0.1183 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.007 | 0.1183 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.007 | 0.1183 | 0.1183 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.8267 | 0.8267 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.007 | 0.1183 | 0.1183 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.007 | 0.1183 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.8267 | 0.8267 |
Schistosoma mansoni | solute carrier family 12 electroneutral k-cl cotransporter | 0.0253 | 1 | 1 |
Onchocerca volvulus | 0.007 | 0.1183 | 0.5 | |
Onchocerca volvulus | 0.007 | 0.1183 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.8267 | 0.8267 |
Echinococcus multilocularis | solute carrier family 12 | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.007 | 0.1183 | 0.1183 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.8267 | 0.8267 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.007 | 0.1183 | 0.1183 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.007 | 0.1183 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.007 | 0.1183 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.007 | 0.1183 | 0.1183 |
Loa Loa (eye worm) | aminopeptidase N | 0.007 | 0.1183 | 0.1183 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.007 | 0.1183 | 0.5 |
Brugia malayi | Amino acid permease family protein | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.8267 | 0.8267 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.007 | 0.1183 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.007 | 0.1183 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.007 | 0.1183 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.007 | 0.1183 | 0.1183 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | > 60 uM | Cytotoxicity against HEK293 cells infected with VSV-G protein pseudotyped HIV1 | ChEMBL. | 25495797 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.