Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | kinesin eg-5 | 0.1172 | 0.1263 | 0.1453 |
Schistosoma mansoni | hypothetical protein | 0.7849 | 0.8696 | 1 |
Plasmodium vivax | kinesin-5 | 0.1172 | 0.1263 | 0.5 |
Entamoeba histolytica | kinesin, putative | 0.1172 | 0.1263 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0149 | 0.0124 | 0.0124 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0121 | 0.0093 | 0.0736 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.1172 | 0.1263 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0121 | 0.0093 | 0.0736 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Giardia lamblia | Kinesin-5 | 0.1172 | 0.1263 | 0.5 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0124 | 0.0982 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0054 | 0.0018 | 0.0145 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0101 | 0.0071 | 0.0071 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Echinococcus multilocularis | kinesin family 1 | 0.902 | 1 | 1 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Plasmodium falciparum | kinesin-5 | 0.1172 | 0.1263 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0037 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0054 | 0.0018 | 0.0145 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0059 | 0.0024 | 0.0191 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0059 | 0.0024 | 0.0028 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0101 | 0.0071 | 0.0082 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Brugia malayi | Kinesin motor domain containing protein | 0.1172 | 0.1263 | 1 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0101 | 0.0071 | 0.0071 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0109 | 0.008 | 0.0636 |
Loa Loa (eye worm) | glutamate receptor | 0.0047 | 0.0011 | 0.0091 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.1172 | 0.1263 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0137 | 0.0111 | 0.0128 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0149 | 0.0124 | 0.0124 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.