Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Telomerase reverse transcriptase | 0.6704 | 0.7232 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.2519 | 0.2635 | 0.5 |
Echinococcus granulosus | protection of telomeres protein 1 | 0.0614 | 0.0541 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.4246 | 0.4531 | 0.6266 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.2519 | 0.2635 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.2519 | 0.2635 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.2519 | 0.2635 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0121 | 0 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.2519 | 0.2635 | 0.5 |
Echinococcus multilocularis | protection of telomeres protein 1 | 0.0614 | 0.0541 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4246 | 0.4531 | 1 |
Brugia malayi | hypothetical protein | 0.4246 | 0.4531 | 0.6266 |
Leishmania major | telomerase reverse transcriptase, putative | 0.2519 | 0.2635 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.2519 | 0.2635 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.2519 | 0.2635 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.