Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 29 (equilibrative nucleoside transporter), member 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Equilibrative nucleoside transporter 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania braziliensis | nucleobase/nucleoside transporter | Equilibrative nucleoside transporter 2 | 456 aa | 381 aa | 26.8 % |
Trypanosoma brucei | purine nucleoside transporter | solute carrier family 29 (equilibrative nucleoside transporter), member 1 | 456 aa | 396 aa | 24.8 % |
Leishmania major | nucleoside transporter 1, putative | Equilibrative nucleoside transporter 2 | 456 aa | 370 aa | 25.1 % |
Leishmania major | nucleoside transporter 1, putative | Equilibrative nucleoside transporter 2 | 456 aa | 370 aa | 25.1 % |
Leishmania mexicana | nucleoside transporter 1, putative | Equilibrative nucleoside transporter 2 | 456 aa | 366 aa | 25.1 % |
Leishmania mexicana | nucleobase transporter | Equilibrative nucleoside transporter 2 | 456 aa | 374 aa | 23.8 % |
Onchocerca volvulus | Equilibrative nucleoside transporter 2 | 456 aa | 452 aa | 27.4 % | |
Leishmania mexicana | nucleoside transporter 1, putative | Equilibrative nucleoside transporter 2 | 456 aa | 365 aa | 24.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.023 | 0.2098 | 0.139 |
Echinococcus multilocularis | aminopeptidase N | 0.0782 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1616 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1616 | 0.0856 |
Echinococcus granulosus | aminopeptidase N | 0.0782 | 1 | 1 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.023 | 0.2098 | 1 |
Echinococcus multilocularis | equilibrative nucleoside transporter 3 | 0.0197 | 0.1616 | 0.0864 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0149 | 0.0939 | 0.4477 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.023 | 0.2098 | 1 |
Echinococcus granulosus | equilibrative nucleoside transporter | 0.0197 | 0.1616 | 0.0864 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.023 | 0.2098 | 1 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.023 | 0.2098 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0149 | 0.0939 | 0.0127 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0633 | 0.7863 | 0.8762 |
Echinococcus multilocularis | equilibrative nucleoside transporter protein | 0.0197 | 0.1616 | 0.0864 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.023 | 0.2098 | 1 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0141 | 0.0823 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.023 | 0.2098 | 1 |
Toxoplasma gondii | leucyl aminopeptidase LAP | 0.0141 | 0.0823 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1616 | 0.0856 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.023 | 0.2098 | 1 |
Chlamydia trachomatis | cytosol aminopeptidase | 0.0141 | 0.0823 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.023 | 0.2098 | 1 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.023 | 0.2098 | 0.139 |
Onchocerca volvulus | 0.023 | 0.2098 | 0.0575 | |
Loa Loa (eye worm) | aminopeptidase N | 0.023 | 0.2098 | 0.1467 |
Brugia malayi | hypothetical protein | 0.023 | 0.2098 | 0.0575 |
Echinococcus granulosus | equilibrative nucleoside transporter 3 | 0.0197 | 0.1616 | 0.0864 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.023 | 0.2098 | 0.139 |
Onchocerca volvulus | 0.0782 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0552 | 0.6704 | 0.7295 |
Loa Loa (eye worm) | hypothetical protein | 0.0701 | 0.8841 | 1 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.023 | 0.2098 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.023 | 0.2098 | 0.139 |
Brugia malayi | Peptidase family M1 containing protein | 0.023 | 0.2098 | 0.0575 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0141 | 0.0823 | 0.5 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0141 | 0.0823 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.023 | 0.2098 | 0.139 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.023 | 0.2098 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.023 | 0.2098 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.023 | 0.2098 | 0.139 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.023 | 0.2098 | 1 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.023 | 0.2098 | 1 |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0084 | 0 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.023 | 0.2098 | 0.139 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.023 | 0.2098 | 0.139 |
Echinococcus multilocularis | equilibrative nucleoside transporter 3 | 0.0162 | 0.1127 | 0.0332 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.023 | 0.2098 | 0.139 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.023 | 0.2098 | 1 |
Giardia lamblia | Hypothetical protein | 0.0197 | 0.1616 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.023 | 0.2098 | 0.139 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0141 | 0.0823 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.2 nM | Inhibition of human ENT1 expressed in porcine PK15NTD cells by cell-based [3H]5-uridine uptake assay | ChEMBL. | 25454272 |
IC50 (binding) | = 1490 nM | Inhibition of rat ENT2 expressed in rat H9c2 cells by cell-based 3H[5-]uridine uptake assay | ChEMBL. | 25454272 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.