Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | glutamine synthetase | 0.0927813 | 0.507419 | 1 |
Plasmodium vivax | glutamine synthetase, putative | 0.0927813 | 0.507419 | 0.5 |
Mycobacterium leprae | PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) | 0.0927813 | 0.507419 | 1 |
Echinococcus multilocularis | conserved hypothetical protein | 0.137363 | 0.989762 | 1 |
Onchocerca volvulus | Glutamine synthetase homolog | 0.0468997 | 0.0110157 | 0.5 |
Schistosoma mansoni | glutamine synthetase bacteria | 0.0677796 | 0.23692 | 1 |
Brugia malayi | Serotonin receptor | 0.0925218 | 0.504612 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) | 0.0927813 | 0.507419 | 1 |
Trypanosoma brucei | glutamine synthetase, putative | 0.0468997 | 0.0110157 | 0.5 |
Loa Loa (eye worm) | Gln-2 protein | 0.0468997 | 0.0110157 | 0.5 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0468997 | 0.0110157 | 0.5 |
Toxoplasma gondii | glutamine synthetase, type I, putative | 0.0927813 | 0.507419 | 0.5 |
Leishmania major | glutamine synthetase, putative | 0.0468997 | 0.0110157 | 0.5 |
Mycobacterium ulcerans | glutamine synthetase GlnA1 | 0.0927813 | 0.507419 | 1 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0468997 | 0.0110157 | 0.5 |
Schistosoma mansoni | glutamine synthetase bacteria | 0.0677796 | 0.23692 | 1 |
Wolbachia endosymbiont of Brugia malayi | glutamine synthetase | 0.0677796 | 0.23692 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.13831 | 1 | 1 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) | 0.0677796 | 0.23692 | 0.466911 |
Plasmodium falciparum | glutamine synthetase, putative | 0.0927813 | 0.507419 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.14 uM | Antileishmanial activity against Leishmania braziliensis MHOM/IT/2006/ISS2848 promastigotes assessed as inhibition of parasite growth after 72 hrs by MTT assay | ChEMBL. | 25497962 |
IC50 (functional) | = 0.17 uM | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay | ChEMBL. | 25497962 |
IC50 (functional) | = 0.23 uM | Antileishmanial activity against Leishmania infantum MHOM/TN/80/IPT1 promastigotes assessed as inhibition of parasite growth after 72 hrs by MTT assay | ChEMBL. | 25497962 |
Ratio IC50 (functional) | = 1.2 | Resistance index, ratio of IC50 for chloroquine-resistant Plasmodium falciparum W2 to IC50 for chloroquine-sensitive Plasmodium falciparum D10 | ChEMBL. | 25497962 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 25497962 | |
Leishmania infantum | ChEMBL23 | 25497962 | |
Leishmania braziliensis | ChEMBL23 | 25497962 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.